Thiram is used in large quantities in agriculture and may contaminate the environment by improper handling or storage in chemical plants and warehouses. A review of the literature has shown that thiram can affect different organs in animals and its toxic mechanisms can be elucidated in more detail at molecular level. We have summarized several impacts of thiram on animals: the effects of the perspectives of oxidative stress, mitochondrial damage, autophagy, apoptosis, and the IHH/PTHrP pathway on regulating abnormal skeletal development in particular tibial dyschondroplasia and kyphosis; angiogenesis inhibition was investigated from the perspective of angiogenesis factor inhibition, PI3K/AKT signaling pathway and CD147; the inhibition effect of thiram on fibroblasts and erythrocytes via the perspective of oxidative stress, mitochondrial damage and inhibition of growth factors in animal skin fibroblasts and erythrocytes; studied fertilized egg size, reduced fertility, neurodegeneration, and immune damage from the perspectives of CYP51 inhibition and dopamine-b-hydroxylase inhibition in the reproductive system, vitamin D deficiency in the nervous system, and inflammatory damage in the immune system; embryonic dysplasia in terms of thyroid hormone repression in animal embryonic development and repression of the SOX9a transcription factor. The elucidation of the mechanisms of toxicity of thiram on various organs of animals at molecular level will enable a more detailed understanding of the mechanisms of toxicity of thiram in animals and will facilitate the exploration of the treatment of thiram poisoning at molecular level.

福美双在农业中大量使用，如果在化工厂和仓库中处理不当或储存不当，可能会污染环境。对文献的回顾表明，福美双可以影响动物的不同器官，并且可以在分子水平上更详细地阐明其毒性机制。我们总结了福美双对动物的几个影响：氧化应激、线粒体损伤、自噬、细胞凋亡和 IHH/PTHrP 途径对调节异常骨骼发育特别是胫骨软骨发育不良和后凸畸形的影响；从血管生成因子抑制、PI3K/AKT信号通路和CD147的角度研究血管生成抑制；从氧化应激的角度研究福美双对成纤维细胞和红细胞的抑制作用，动物皮肤成纤维细胞和红细胞中的线粒体损伤和生长因子抑制；从生殖系统CYP51抑制和多巴胺-b-羟化酶抑制、神经系统维生素D缺乏、免疫系统炎症损伤等角度研究受精卵大小、生育力降低、神经退行性变和免疫损伤；胚胎发育不良在动物胚胎发育中的甲状腺激素抑制和 SOX9a 转录因子的抑制方面。从分子水平阐明福美双对动物各器官的毒性机制，将有助于更详细地了解福美双在动物体内的毒性机制，有助于在分子水平上探索福美双中毒的治疗方法。