S100 钙结合蛋白 A7 (S100A7) 在人类肿瘤中的致癌作用的泛癌分析,Biology

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S100 钙结合蛋白 A7 (S100A7) 在人类肿瘤中的致癌作用的泛癌分析
Biology ( IF 3.796 ) Pub Date : 2022-02-14 , DOI: 10.3390/biology11020284
Ge Peng _{1,

2} , Saya Tsukamoto _{1,

2} , Ko Okumura ₂ , Hideoki Ogawa ₂ , Shigaku Ikeda _{1,

2} , François Niyonsaba _{2,

3}

Affiliation

背景：虽然新兴研究支持 S100 钙结合蛋白 A7 (S100A7) 与各种癌症之间的关系，但迄今为止尚无 S100A7 的泛癌分析。方法：我们根据癌症基因组图谱 (TCGA) 和基因表达综合 (GEO) 的数据集研究了 S100A7 在 33 个肿瘤中的潜在致癌作用。此外，使用基因表达谱交互分析（GEPIA）网络服务器和Kaplan-Meier绘图仪进行生存预后分析，然后进行S100A7的遗传改变分析和S100A7相关基因的富集分析。结果：S100A7在大多数类型的癌症中高表达，S100A7的表达与癌症患者的预后存在显着相关性。S100A7的表达与头颈部鳞状细胞癌中DNA甲基转移酶和错配修复基因的表达、不同肿瘤中CD8+ T细胞和癌相关成纤维细胞的浸润有关。此外，糖胺聚糖降解和溶酶体相关功能参与了 S100A7 的功能机制。结论：目前的泛癌研究显示了对 S100A7 在多种癌症中的致癌作用的相对综合理解。

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A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors

Background: Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far. Methods: We investigated the potential oncogenic roles of S100A7 across 33 tumors based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Moreover, a survival prognosis analysis was performed with the gene expression profiling interactive analysis (GEPIA) web server and Kaplan–Meier plotter, followed by the genetic alteration analysis of S100A7 and enrichment analysis of S100A7-related genes. Results: S100A7 was highly expressed in most types of cancers, and remarkable associations were found between S100A7 expression and the prognosis of cancer patients. S100A7 expression was associated with the expression of DNA methyltransferase and mismatch repair genes in head and neck squamous cell carcinoma, the infiltration of CD8+ T cells and cancer-associated fibroblasts in different tumors. Moreover, glycosaminoglycan degradation and lysosome-associated functions were involved in the functional mechanisms of S100A7. Conclusions: The current pancancer study shows a relatively integrative understanding of the carcinogenic involvement of S100A7 in numerous types of cancers.

更新日期：2022-02-14

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