Fluorination and Betaine Modification Augment the Blood–Brain Barrier-Crossing Ability of Cylindrical Polymer Brushes,Angewandte Chemie International Edition

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Fluorination and Betaine Modification Augment the Blood–Brain Barrier-Crossing Ability of Cylindrical Polymer Brushes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-10 , DOI: 10.1002/anie.202201390
Ruonan Wang ₁ , Shuo Yang ₁ , Panpan Xiao ₁ , Ying Sun ₁ , Jia Li ₁ , Xiqun Jiang ₁ , Wei Wu ₁

Affiliation

It is found that fluorination augments the blood–brain barrier (BBB) penetration of cylindrical polymer brushes by altering the surface state, and betaine modification achieves this function via a betaine transporter BGT1 expressed on brain capillaries.

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