早期养宠物与哮喘和过敏致敏的关联：对来自欧盟儿童队列网络的 77,000 多名儿童的荟萃分析,Journal of Allergy and Clinical Immunology

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早期养宠物与哮喘和过敏致敏的关联：对来自欧盟儿童队列网络的 77,000 多名儿童的荟萃分析
Journal of Allergy and Clinical Immunology ( IF 11.4 ) Pub Date : 2022-02-10 , DOI: 10.1016/j.jaci.2022.01.023
Angela Pinot de Moira ₁ , Katrine Strandberg-Larsen ₁ , Tom Bishop ₂ , Marie Pedersen ₁ , Demetris Avraam ₃ , Tim Cadman ₄ , Lucinda Calas ₅ , Maribel Casas ₆ , Blandine de Lauzon Guillain ₅ , Ahmed Elhakeem ₄ , Ana Esplugues ₇ , Marisa Estarlich ₇ , Rachel E Foong ₈ , Sido Haakma ₉ , Jennifer R Harris ₁₀ , Rae-Chi Huang ₁₁ , Hazel Inskip ₁₂ , Aitana Lertxundi ₁₃ , Sara M Mensink-Bout ₁₄ , Johanna L T Nader ₁₅ , Costanza Pizzi ₁₆ , Maja Popovic ₁₆ , Theodosia Salika ₁₇ , Jordi Sunyer ₁₈ , Evelien R Van Meel ₁₄ , Morris A Swertz ₁₉ , Vincent W V Jaddoe ₁₄ , Paul Burton ₃ , Liesbeth Duijts ₁₄ , Anne-Marie Nybo Andersen ₁

Affiliation

Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Population Health Sciences Institute, Newcastle University, Newcastle, United Kingdom.
Population Health Science, Bristol Medical School, Bristol, United Kingdom; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
Université de Paris, Centre for Research in Epidemiology and Statistics, INSERM, INRAE, Paris, France.
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain.
Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Department of Nursing, University of Valencia, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, The Foundation for the Promotion of Health and Biomedical Research of Valencia Region, Universitat Jaume I-Universitat de València, Valencia, Spain.
Telethon Kids Institute, Perth, Australia; School of Allied Health, Curtin University, Perth, Australia.
Genomics Coordination Center, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Telethon Kids Institute, Perth, Australia.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Basque Country, Leioa, Spain; Biodonostia Health Research Institute, San Sebastian, Spain.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health, Madrid, Spain; Imim-ParcSalutMar, Spain.
Genomics Coordination Center, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, the University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

背景

检查早期养猫和养狗与儿童哮喘之间的关联的研究报告了不一致的结果。有几个因素可以解释这些不一致，包括宠物的类型、时间和接触程度。

客观的

我们的目的是研究早期养猫和养狗与学龄儿童哮喘的关系，包括类型（猫与狗）、时间（从不、产前或儿童早期）和拥有程度（数量的宠物拥有），以及过敏致敏的作用。

方法

当孩子 5 至 11 岁时，我们使用了来自欧盟儿童队列网络中 9 个出生队列的 77,434 名母子的统一数据。通过 DataSHIELD 平台使用调整后的逻辑回归模型检查关联，这些模型分别为每个队列拟合，并通过使用随机效应荟萃分析进行组合。

结果

早期养猫和养狗的患病率分别为 12% 至 45% 和 7% 至 47%，哮喘患病率范围为 2% 至 20%。养猫或养狗与哮喘之间没有总体关联（优势比 [OR] = 0.97 [95% CI = 0.87-1.09] 和 0.92 [95% CI = 0.85-1.01]）。时间和所有权程度并没有强烈影响协会。养猫和养狗也与猫和狗特异性过敏致敏无关（分别为 OR = 0.92 [95% CI = 0.75-1.13] 和 0.93 [95% CI = 0.57-1.54]）。然而，猫和狗特异性过敏与学龄期哮喘密切相关（OR = 6.69 [95% CI = 4.91-9.10] 和 5.98 [95% CI = 3.14-11.36]）。还有一些迹象表明所有权和宣传之间存在相互作用，

结论

我们的研究结果不支持早期养猫和养狗本身会增加学龄期哮喘的风险，但它们确实表明养猫可能会加剧与猫和狗特异性过敏致敏相关的风险。

"点击查看英文标题和摘要"

Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network

Background

Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet, timing, and degree of exposure.

Objective

Our aim was to study associations of early-life cat and dog ownership with asthma in school-aged children, including the role of type (cat vs dog), timing (never, prenatal, or early childhood), and degree of ownership (number of pets owned), and the role of allergic sensitization.

Methods

We used harmonized data from 77,434 mother-child dyads from 9 birth cohorts in the European Union Child Cohort Network when the child was 5 to 11 years old. Associations were examined through the DataSHIELD platform by using adjusted logistic regression models, which were fitted separately for each cohort and combined by using random effects meta-analysis.

Results

The prevalence of early-life cat and dog ownership ranged from 12% to 45% and 7% to 47%, respectively, and the prevalence of asthma ranged from 2% to 20%. There was no overall association between either cat or dog ownership and asthma (odds ratio [OR] = 0.97 [95% CI = 0.87-1.09] and 0.92 [95% CI = 0.85-1.01], respectively). Timing and degree of ownership did not strongly influence associations. Cat and dog ownership were also not associated with cat- and dog-specific allergic sensitization (OR = 0.92 [95% CI = 0.75-1.13] and 0.93 [95% CI = 0.57-1.54], respectively). However, cat- and dog-specific allergic sensitization was strongly associated with school-age asthma (OR = 6.69 [95% CI = 4.91-9.10] and 5.98 [95% CI = 3.14-11.36], respectively). There was also some indication of an interaction between ownership and sensitization, suggesting that ownership may exacerbate the risks associated with pet-specific sensitization but offer some protection against asthma in the absence of sensitization.

Conclusion

Our findings do not support early-life cat and dog ownership in themselves increasing the risk of school-age asthma, but they do suggest that ownership may potentially exacerbate the risks associated with cat- and dog-specific allergic sensitization.

更新日期：2022-02-10

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