A number of photoinitiators are available in chemical industry, but less of them in biomedicine or clinical therapy due to the limitation of their cytotoxicity and biocompatibility. Thus, it is urgently necessary to find non-toxic or low-toxic photoinitiators to meet clinical demands. Aceanthrenequinone (AATQ) is a novel photosensitizer with high-photoinitiating ability, but no reports contribute, to date, to its cytotoxicity and biocompatibility. Here, primary cells and various cell lines were exposed to different concentrations of AATQ with or without irradiation. AATQ had the similar photoinitiating conversion efficiency to the extensively used bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide (BAPO) and higher one than 9,10-phenanthrenequinone (PANQ) with the similar extent of polymerization in depth within a certain range, but displayed much lower cytotoxicity than BAPO under non-irradiation or irradiation. The biocompatibility of BisGMA/TEGDMA polymer prepared by AATQ was superior to that of PANQ, but inferior to that of camphorquinone (CQ) although the far lower dose of AATQ is enough to initiate polymerization of monomer than that of CQ. Hence, AATQ offers a valuable alternative in applications of industrial or biomedical areas.

中文翻译：

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新型光引发剂苊醌引发的聚合特性及其引发的聚合物的细胞相容性


许多光引发剂可用于化学工业，但由于其细胞毒性和生物相容性的限制，在生物医学或临床治疗中的应用较少。因此，迫切需要寻找无毒或低毒的光引发剂来满足临床需求。乙酰醌（AATQ）是一种具有高光引发能力的新型光敏剂，但迄今为止尚未有关于其细胞毒性和生物相容性的报道。在此，将原代细胞和各种细胞系暴露于不同浓度的 AATQ，有或没有照射。 AATQ与广泛使用的双(2,4,6-三甲基苯甲酰基)-苯基氧化膦(BAPO)具有相似的光引发转化效率，并且比9,10-菲醌(PANQ)高1倍，并且在一定深度内聚合程度相似。范围内，但在非照射或照射下表现出比 BAPO 低得多的细胞毒性。 AATQ制备的BisGMA/TEGDMA聚合物的生物相容性优于PANQ，但不如樟脑醌(CQ)，尽管AATQ的剂量远低于CQ足以引发单体聚合。因此，AATQ 在工业或生物医学领域的应用中提供了一个有价值的替代方案。