Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis,Angewandte Chemie International Edition

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Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-02-09 , DOI: 10.1002/anie.202117324
Lucy C Ward ₁ , Hannah V McCue ₂ , Daniel J Rigden ₃ , Neil M Kershaw ₁ , Chloe Ashbrook ₁ , Harry Hatton ₁ , Ellie Goulding ₁ , James R Johnson ₂ , Andrew J Carnell ₁

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The carboxyl methyltransferase FtpM can catalyse methylation and dimethylation of a wide range of mono- and dicarboxylic acids, showing high regioselectivity for some diacids. The enzymatic methylation works under aqueous conditions and can therefore be integrated into enzyme cascades as demonstrated by the two-step, one-pot conversion of bioderived HMF to bioplastics precursor FDME.

中文翻译：

羧甲基转移酶在水条件下催化单甲酯和二甲酯的形成：在级联生物催化中的应用

羧甲基转移酶 FtpM 可以催化多种单羧酸和二羧酸的甲基化和二甲基化，对某些二酸表现出高区域选择性。酶促甲基化在水性条件下进行，因此可以整合到酶级联中，如生物源 HMF 向生物塑料前体 FDME 的两步一锅转化所证明的那样。

更新日期：2022-02-09

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