Near-Infrared Fluorescent Heptamethine Cyanine Dyes for COX-2 Targeted Photodynamic Cancer Therapy,ChemMedChem

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Near-Infrared Fluorescent Heptamethine Cyanine Dyes for COX-2 Targeted Photodynamic Cancer Therapy
ChemMedChem ( IF 3.6 ) Pub Date : 2022-02-07 , DOI: 10.1002/cmdc.202100780
Sirilak Wangngae ₁ , Siriwalee Siriwibool ₁ , Kantapat Chansaenpak ₂ , Sirawit Wet-Osot ₃ , Rung-Yi Lai ₁ , Anyanee Kamkaew ₁

Affiliation

Two I-IR799 derivatives are NIR-absorbing probes that can be activated for photodynamic therapy (PDT). I-IR799-IMC, containing indomethacin, exhibits superior cancer targeting and PDT performance relative to another probe containing celecoxib (I-IR799-CXB). I-IR799-IMC can be rapidly internalized via OATPs and recognized by cancer cells which is demonstrated to be related to COX-2 levels.

中文翻译：

用于 COX-2 靶向光动力癌症治疗的近红外荧光七次甲基花青染料

两种 I-IR799 衍生物是 NIR 吸收探针，可被激活用于光动力疗法 (PDT)。与另一种含有塞来昔布的探针 (I-IR799-CXB) 相比，含有吲哚美辛的 I-IR799-IMC 表现出优异的癌症靶向和 PDT 性能。I-IR799-IMC 可以通过 OATP 快速内化并被癌细胞识别，这被证明与 COX-2 水平有关。

更新日期：2022-02-07

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