Abstract

Three new dibenzofurans, 2-hydroxy-3,4-dimethoxydibenzofuran (1), 2,8-dihydroxy-3,4,9-trimethoxydibenzofuran (5) and 2-hydroxy-3,4,6,8-tetramethoxydibenzofuran (6), together with three known dibenzofurans 1-hydroxy-2,3,4-trimethoxydibenzofuran (2), 2-hydroxy-3,4,6-trimethoxydibenzofuran (3) and 1,6-dihydroxy-2,3,4-trimethoxydibenzofuran (4), were isolated from the twigs and leaves of Crataegus oresbia. Their structures were identified by the comprehensive analyses of the physicochemical properties and spectroscopic data (NMR and HR-ESI-MS). Compounds 1–3 showed significant in vitro lipid-lowering activities, especially compound 3 was stronger than simvastatin.

摘要

三种新的二苯并呋喃，2-hydroxy-3,4-dimethoxydibenzofuran ( 1 ), 2,8-dihydroxy-3,4,9-trimethoxydibenzofuran ( 5 ) 和 2-hydroxy-3,4,6,8-tetramethoxydibenzofuran ( 6 ) , 以及三种已知的二苯并呋喃 1-hydroxy-2,3,4-trimethoxydibenzofuran ( 2 ), 2-hydroxy-3,4,6-trimethoxydibenzofuran ( 3 ) 和 1,6-dihydroxy-2,3,4-trimethoxydibenzofuran ( 4 ),是从山楂的枝叶中分离得到的。通过对物理化学性质和光谱数据（NMR 和 HR-ESI-MS）的综合分析确定了它们的结构。化合物1-3在体外表现出显着性降脂作用，尤其是化合物3比辛伐他汀强。