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Naked-Eye Detection of Hydrogen Peroxide on Photoluminescent Paper Discs
ACS Sensors ( IF 8.2 ) Pub Date : 2022-02-04 , DOI: 10.1021/acssensors.1c02322 Arnab Dutta 1 , Uday Maitra 1
ACS Sensors ( IF 8.2 ) Pub Date : 2022-02-04 , DOI: 10.1021/acssensors.1c02322 Arnab Dutta 1 , Uday Maitra 1
Affiliation
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We have developed a turn-on photoluminescence protocol to detect hydrogen peroxide (H2O2) utilizing a supramolecular hydrogel as a sensing platform. Hydrogen peroxide is widely used in formulations, starting from healthcare products to explosives. It is also known to induce deleterious health effects at its irregular physiological concentration and considered as a biomarker in various disease conditions. We designed molecule 2, which releases the Tb3+ sensitizer biphenyl-4-carboxylic acid (1) upon unmasking by hydrogen peroxide. This chemistry led us to develop a sensitive photoluminescence assay for H2O2 through the 1-induced photoluminescence of terbium (Tb3+) in a hydrogel matrix. Paper discs (0.45 cm) were coated with the soft hydrogel to make the sensing process simple and cost-effective. The green luminescence from the paper discs, observed under a UV lamp, allowed naked-eye detection of H2O2 in the micromolar level without any sophisticated instrumentation. Image processing software or a plate reader can be used for the accurate quantification of the analyte in micromolar and nanomolar ranges. Several commercial hand sanitizers containing hydrogen peroxide were tested by this method. The results indicated that this low-cost system could be practically adopted, especially in resource-limited areas, to quantify/detect H2O2 for quality control purposes or other applications.
中文翻译：
光致发光纸盘上过氧化氢的肉眼检测
我们开发了一种开启光致发光协议，利用超分子水凝胶作为传感平台来检测过氧化氢 (H 2 O 2 )。过氧化氢广泛用于配方中，从保健品到炸药。还已知在其不规则的生理浓度下会引起有害的健康影响，并被认为是各种疾病状况的生物标志物。我们设计了分子2 ，它在被过氧化氢暴露后释放 Tb 3+敏化剂联苯-4-羧酸 ( 1 )。这种化学反应使我们开发了一种灵敏的 H 2 O 2光致发光检测方法，通过1-水凝胶基质中铽 (Tb 3+ ) 的诱导光致发光。纸盘（0.45 厘米）涂有软水凝胶，使传感过程简单且具有成本效益。在紫外灯下观察到纸盘发出的绿色荧光，无需任何复杂的仪器就可以肉眼检测微摩尔水平的 H 2 O 2。图像处理软件或读板器可用于对微摩尔和纳摩尔范围内的分析物进行准确定量。通过这种方法测试了几种含有过氧化氢的商业洗手液。结果表明，这种低成本的系统可以被实际采用，特别是在资源有限的地区，用于量化/检测 H 2 O 2用于质量控制或其他应用。
更新日期：2022-02-04
中文翻译：
光致发光纸盘上过氧化氢的肉眼检测
我们开发了一种开启光致发光协议，利用超分子水凝胶作为传感平台来检测过氧化氢 (H 2 O 2 )。过氧化氢广泛用于配方中，从保健品到炸药。还已知在其不规则的生理浓度下会引起有害的健康影响，并被认为是各种疾病状况的生物标志物。我们设计了分子2 ，它在被过氧化氢暴露后释放 Tb 3+敏化剂联苯-4-羧酸 ( 1 )。这种化学反应使我们开发了一种灵敏的 H 2 O 2光致发光检测方法，通过1-水凝胶基质中铽 (Tb 3+ ) 的诱导光致发光。纸盘（0.45 厘米）涂有软水凝胶，使传感过程简单且具有成本效益。在紫外灯下观察到纸盘发出的绿色荧光，无需任何复杂的仪器就可以肉眼检测微摩尔水平的 H 2 O 2。图像处理软件或读板器可用于对微摩尔和纳摩尔范围内的分析物进行准确定量。通过这种方法测试了几种含有过氧化氢的商业洗手液。结果表明，这种低成本的系统可以被实际采用，特别是在资源有限的地区，用于量化/检测 H 2 O 2用于质量控制或其他应用。
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