Semisynthesis of (−)-Bufospirostenin A Enabled by Photosantonin Rearrangement Reaction,Journal of the American Chemical Society

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Semisynthesis of (−)-Bufospirostenin A Enabled by Photosantonin Rearrangement Reaction
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2022-02-03 , DOI: 10.1021/jacs.1c12395
Jun Huang ₁ , Tingting Cao ₁ , Zhongchao Zhang ₁ , Zhen Yang _{1,

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Affiliation

An enantioselective semisynthesis of (−)-bufospirostenin A is described. The key steps in the synthesis involve use of our proposed biomimetic and diastereoselective photosantonin rearrangement reaction for construction of the 5/7 bicyclic motif, and a Co-catalyzed reversible double-bond isomerization reaction for installing the double bond in the seven-membered ring.

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