A series of 4-alkyl/aryl-2,4-dihydro-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)methyl)-3H-1,2,4-triazole-3-thiones (3a–i) and 2-alkyl/arylamino-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)methyl)-1,3,4-thiadiazoles (4a–c) were synthesized starting from 6-(4-bromophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. The newly synthesized compounds were characterized by IR, ¹H NMR, mass and elemental analysis. All compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H₃₇Rv (ATCC 27294). The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.

一系列4-烷基/芳基-2,4-二氢-5-（（6-（4-溴苯基）咪唑并[2,1 - b ]噻唑-3-基）甲基）-3 H -1,2， 4-三唑-3-硫酮（3a – i）和2-烷基/芳基氨基-5-（（6-（4-溴苯基）咪唑并[2,1- b ]噻唑-3-基）甲基）-1,3从6-（4-溴苯基）咪唑并[2,1 - b ]噻唑-3-乙酸酰肼开始合成了4-4-噻二唑（4a – c）。新合成的化合物的特征在于IR，¹1 H NMR，质量和元素分析。测试所有化合物的抗菌和抗真菌活性。通过微肉汤稀释技术评估化合物的抗微生物活性。还评估了这些化合物对结核分枝杆菌H ₃₇ Rv（ATCC 27294）的抗结核活性。初步结果表明，某些化合物显示出有希望的抗菌活性。