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A DNase-mimetic artificial enzyme for the eradication of drug-resistant bacterial biofilm infections
Nanoscale ( IF 5.8 ) Pub Date : 2022-01-19 , DOI: 10.1039/d1nr07629a Haolu Hu 1, 2 , Xiaoxia Kang 2 , Zhenhua Shan 1 , Xiaoxiao Yang 2 , Wei Bing 1 , Li Wu 2 , Haiyan Ge 3 , Haiwei Ji 2
Nanoscale ( IF 5.8 ) Pub Date : 2022-01-19 , DOI: 10.1039/d1nr07629a Haolu Hu 1, 2 , Xiaoxia Kang 2 , Zhenhua Shan 1 , Xiaoxiao Yang 2 , Wei Bing 1 , Li Wu 2 , Haiyan Ge 3 , Haiwei Ji 2
Affiliation
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The construction of multifunctional nano-enzymes is a feasible strategy for fighting multi-drug resistant (MDR) bacterial biofilm-associated infections. Extracellular DNA (eDNA) is an important functional part of biofilm formation, including the initial adherence of bacteria to subsequent development and eventual maturation. A nano-enzyme platform of graphene oxide-based nitrilotriacetic acid-cerium(IV) composite (GO-NTA-Ce) against bacterial biofilm infection has been developed. When located at the site of bacteria-associated infection, GO-NTA-Ce could inhibit the biofilm formation and effectively disperse the formed biofilm by degrading the eDNA. In addition to Ce-mediated deoxyribonuclease (DNase)-like activity, near-infrared laser irradiation of GO-NTA-Ce could produce local hyperthermia to kill the bacteria that lost the protection by the biofilm matrix. In addition, graphene is also a new green broad-spectrum antimicrobial material that can exert its antimicrobial effects through physical damage and chemical damage. In short, our GO-NTA-Ce nano-enzyme platform is capable of effectively eradicating drug-resistant bacterial biofilm infections through the triple action of DNase-like enzyme properties, photothermal therapy, and graphene-based antimicrobial activity, and the nano-composite has excellent potential for the treatment of MDR bacterial biofilm infections.
中文翻译：
一种用于根除耐药细菌生物膜感染的 DNase 模拟人工酶
多功能纳米酶的构建是对抗多重耐药（MDR）细菌生物膜相关感染的可行策略。细胞外 DNA (eDNA) 是生物膜形成的重要功能部分，包括细菌对随后发育和最终成熟的最初粘附。一种基于氧化石墨烯的次氮基三乙酸-铈纳米酶平台( IV) 已开发出抗细菌生物膜感染的复合材料 (GO-NTA-Ce)。当位于细菌相关感染部位时，GO-NTA-Ce 可以通过降解 eDNA 来抑制生物膜的形成并有效地分散形成的生物膜。除了 Ce 介导的脱氧核糖核酸酶 (DNase) 样活性外，GO-NTA-Ce 的近红外激光照射可以产生局部热疗来杀死失去生物膜基质保护的细菌。此外，石墨烯还是一种新型绿色广谱抗菌材料，可通过物理损伤和化学损伤发挥其抗菌作用。简而言之，我们的 GO-NTA-Ce 纳米酶平台能够通过类 DNase 酶特性、光热疗法、
更新日期：2022-01-19
中文翻译：
一种用于根除耐药细菌生物膜感染的 DNase 模拟人工酶
多功能纳米酶的构建是对抗多重耐药（MDR）细菌生物膜相关感染的可行策略。细胞外 DNA (eDNA) 是生物膜形成的重要功能部分，包括细菌对随后发育和最终成熟的最初粘附。一种基于氧化石墨烯的次氮基三乙酸-铈纳米酶平台( IV) 已开发出抗细菌生物膜感染的复合材料 (GO-NTA-Ce)。当位于细菌相关感染部位时，GO-NTA-Ce 可以通过降解 eDNA 来抑制生物膜的形成并有效地分散形成的生物膜。除了 Ce 介导的脱氧核糖核酸酶 (DNase) 样活性外，GO-NTA-Ce 的近红外激光照射可以产生局部热疗来杀死失去生物膜基质保护的细菌。此外，石墨烯还是一种新型绿色广谱抗菌材料，可通过物理损伤和化学损伤发挥其抗菌作用。简而言之，我们的 GO-NTA-Ce 纳米酶平台能够通过类 DNase 酶特性、光热疗法、
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