Continuous administration of most chemotherapeutic drugs can induce different types of side effects. There has been growing interest in exploring an alternative approach to synthesizing compounds that are most effective and have fewer side effects. We synthesized 29H,31H-Phthalocyanine, and Chloro (29H,31H- phthalocyaninato) aluminum at low temperatures using lithium in the present study with diisopropylamide as the nucleophile. The physical characteristics of 29H,31H-Phthalocyanine, and Chloro (29H,31H- phthalocyaninato) aluminum were confirmed by FT-IR method, XRD, SEM, and the impact of these compounds on human colorectal carcinoma (HCT-116) and human cervical cells (HeLa) was examined. Treatment with 29H,31H-Phthalocyanine significantly decreased cancer cell growth and proliferation, as determined by MTT and DAPI staining analysis. In contrast, Chloro (29H,31H- phthalocyaninato) aluminum treatment did not show any inhibitory action on colon or cervical cancer cells. We also calculated the inhibitory concentration (IC50) of 29H,31H-Phthalocyanine, which was 30 µg/ml (HCT-116) and 33 µg/ml (HeLa cells). The antibacterial effectiveness of 29H,31H-Phthalocyanine, and chloro (29H,31H- phthalocyaninato) aluminum was studied using Enterococcus faecalis (E. faecalis). The CFU (colony frequency unit) assay confirmed significant activity against the test bacterium after treatment with 29H,31H-Phthalocyanine. However, no activity was seen upon treatment with chloro (29H,31H- phthalocyaninato) aluminum against E. faecalis.

大多数化疗药物的连续给药会引起不同类型的副作用。人们越来越有兴趣探索一种替代方法来合成最有效且副作用更少的化合物。在本研究中，我们以二异丙基酰胺为亲核试剂，在低温下使用锂合成了 29H,31H-酞菁和氯（29H,31H-酞菁）铝。29H,31H-酞菁和氯(29H,31H-酞菁)铝的物理特性通过FT-IR、XRD、SEM等方法证实，以及这些化合物对人结直肠癌(HCT-116)和人宫颈癌的影响检查细胞（HeLa）。通过 MTT 和 DAPI 染色分析确定，用 29H,31H-酞菁处理显着降低了癌细胞的生长和增殖。相比之下，氯（29H,31H-酞菁）铝处理对结肠癌细胞或宫颈癌细胞没有表现出任何抑制作用。我们还计算了 29H,31H-酞菁的抑制浓度 (IC50)，分别为 30 µg/ml (HCT-116) 和 33 µg/ml (HeLa 细胞)。研究了 29H,31H-酞菁和氯（29H,31H-酞菁）铝的抗菌效果粪肠球菌（E. faecalis）。CFU（菌落频率单位）测定证实在用 29H,31H-酞菁处理后对测试细菌有显着的活性。然而，在用氯（29H，31H-酞菁）铝处理后，没有观察到对粪肠球菌的活性。