<br>通过萃取溶剂升华和溶剂萃取方法及优化从稀水性进料中回收L-色氨酸,Journal of Molecular Liquids

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通过萃取溶剂升华和溶剂萃取方法及优化从稀水性进料中回收L-色氨酸
Journal of Molecular Liquids ( IF 5.3 ) Pub Date : 2022-01-30 , DOI: 10.1016/j.molliq.2022.118627
Sourav Poddar ₁ , Jasmina Khanam ₂

Affiliation

本研究旨在从稀水溶液中回收 L-色氨酸。 L-色氨酸是一种必需氨基酸，可作为抗抑郁药物治疗的辅助药物。回收方法基于萃取，例如传统溶剂萃取和萃取溶剂冲刷。该技术的执行要考虑几个因素：萃取剂、表面活性剂的量、初始 pH 值和氮气流速 (GFR)。该程序使用 Statease Design Expert 统计软件通过响应面法进行优化。生成设计模型来评估氨基酸的两种反应％回收率(RP)和富集率(ER)。经过验证的模型可以很好地解释因素的影响、因素之间相互作用的影响以及二次效应。在“溶剂萃取”方法中，通过试验改变了各种控制参数。当氨基酸与十二烷基硫酸钠的摩尔比(1:1)、氨基酸与萃取剂的摩尔比(1:1500)、二-(2-乙基己基)磷酸，水-有机物体积比为3:1。在“溶剂冲刷法”中，观察到最大% RP 和 ER 分别为 ∼ 74.77% 和 3.552。 0.968 的高合意性值表明模型的适用性。该方法环保、简单、成本较低、不需要电力。萃取溶剂升华优于传统溶剂萃取，因为前者可以使用较少量的溶剂进行操作。

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Recovery of l-tryptophan from dilute aqueous feed by extractive solvent sublation and solvent extraction methods and optimization

The present investigation aims to recover l-tryptophan from a dilute aqueous solution. L-tryptophan, an essential amino acid, is indicated as an adjunct to antidepressant drug treatment. The recovery method is based on extraction such as conventional Solvent Extraction and Extractive Solvent Sublation. The technique is executed considering several factors: amounts of extractant, surfactant, initial pH, and flow rate of nitrogen gas (GFR). The procedure is optimized by response surface methodology using Statease Design Expert statistical software. Design models were generated to assess two responses% Recovery (RP) and Enrichment (ER) of amino acid. The validated models could explain well the effects of factors, the impact of the interaction between factors, and the quadratic effects. In the ‘solvent extraction’ method, various controlling parameters were varied by trial. Maximum percentage of extraction of amino acid of 70.29 and partition coefficient of 7.276 was observed at mole ratio (1:1) of amino acid and sodium lauryl sulfate, mole ratio (1:1500) of amino acid and extractant, Di-(2-Ethylhexyl) phosphoric acid, the aqueous- organic volume ratio of 3:1. In the ‘solvent sublation method, maximum% RP and ER were observed as ∼ 74.77% and 3.552. A high desirability value of 0.968 indicates the suitability of the models. The method is eco-friendly, simple, less costly, and does not require electricity. The extractive solvent sublation is preferred over conventional solvent extraction as the former can be operated with a lesser quantity of solvent.

更新日期：2022-01-30

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