The organic solvent nanofiltration (OSN) membranes are an attractive candidate that enable carbon-neutral nature in both isolation and purification process. However, the application of current commercial available OSN membranes is severely hindered by their inferior permeability and selectivity. Here, using poly(m-phenylene isophthalamide) (PMIA) as support, a thin film composite (TFC) membrane with remarkably high permeability and ideal selectivity is fabricated in an industrial-scale manufacturing line and the relevant spiral-would module is successfully prepared. Optimization by the solvent activated, the TFC membrane with an extraordinary solvent permeation for acetone, methanol and acetonitrile are 63, 41 and 38 L m⁻² h⁻¹∙bar⁻¹, respectively. The nanofiltration performance of A-TFC membrane supports out-performs: at similar rejection (100%) the methanol and acetonitrile permeance increased dramatically at 10 and 5 times than current commercial OSN membranes, respectively. The spiral-would module is carried out in methanol and acetonitrile RB (1017 g mol⁻¹) solution, which displays a high permeate fluxes and stable separation performances, methanol: 112 GPD, 98%; acetonitrile: 99 GPD, 99.3%. This work provided a large-scale facile process for high-performance PMIA based OSN membrane, and the fabrication of spiral-would module, which should be promising for manufacture of solvent-resistant TFC membrane in industrial scale-up.

有机溶剂纳滤 (OSN) 膜是一种有吸引力的候选物，它在分离和纯化过程中均能实现碳中性。然而，目前市售的 OSN 膜的应用受到其较差的渗透性和选择性的严重阻碍。在这里，以聚（间苯二甲酰胺）（PMIA）为载体，在工业规模的生产线上制造了具有显着高渗透性和理想选择性的薄膜复合（TFC）膜，并成功制备了相关的螺旋形组件. 通过溶剂活化优化，TFC 膜对丙酮、甲醇和乙腈具有非凡的溶剂渗透性，分别为 63、41 和 38 L m ^-2  h ^-1 ∙bar ^-1， 分别。A-TFC 膜的纳滤性能表现出众：在相似的截留率 (100%) 下，甲醇和乙腈的渗透率分别比目前的商用 OSN 膜高出 10 倍和 5 倍。螺旋模块在甲醇和乙腈RB (1017 g mol ^-1 ) 溶液中进行，具有高渗透通量和稳定的分离性能，甲醇：112 GPD，98%；乙腈：99 GPD，99.3%。这项工作为高性能 PMIA 基 OSN 膜的大规模生产提供了一种简便的工艺，并提供了螺旋管模块的制造，这对于在工业规模化中制造耐溶剂 TFC 膜具有广阔的前景。