A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones were designed, synthesized, and evaluated as anticancer agents. Among them, two compounds demonstrated potent cytotoxicity and topoisomerase I inhibitory activity. In addition, their possible binding modes with topoisomerase I/DNA complex were proposed on the basis of molecular docking results.

中文翻译：

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新型噻唑并[4,5-d]嘧啶-7(6H)-ones作为拓扑异构酶I抑制剂的合成及生物学评价

设计、合成了一系列新型噻唑并[4,5 - d ]嘧啶-7(6 H )-酮作为抗癌剂。其中，两种化合物表现出强大的细胞毒性和拓扑异构酶 I 抑制活性。此外，在分子对接结果的基础上，提出了它们与拓扑异构酶I/DNA复合物可能的结合方式。