Photocatalytic oxidative benzylic bromination with hydrobromic acid (HBr) and hydrogen peroxide (H₂O₂) is a green process for the synthesis of benzyl bromides, but suffers from the risk of explosion when performing it in a batch reactor. This disadvantage could be overcome by running the reaction in a microchannel reactor. In this work, a green and safe process for the synthesis of 2,6-dichlorobenzyl bromide (DCBB) was developed by conducting selective benzylic bromination of 2,6-dichlorotoluene (DCT) with H₂O₂ as an oxidant and HBr as a bromine source in a microchannel reactor under light irradiation. The reaction parameters were optimized, and the conversion of DCT reached up to 98.1% with a DCBB yield of 91.4% under the optimal reaction conditions.

中文翻译：

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微通道反应器中2,6-二氯甲苯光催化氧化溴化制2,6-二氯苄基溴

氢溴酸 (HBr) 和过氧化氢 (H ₂ O ₂ ) 的光催化氧化苄基溴化是合成苄基溴的绿色工艺，但在间歇反应器中进行时存在爆炸的风险。这个缺点可以通过在微通道反应器中进行反应来克服。_{本工作以 H 2} O ₂对 2,6-二氯甲苯 (DCT) 进行选择性苄基溴化，开发了一种绿色安全的 2,6-二氯苄基溴 (DCBB) 合成工艺。在光照射下的微通道反应器中作为氧化剂和 HBr 作为溴源。对反应参数进行了优化，在最佳反应条件下，DCT的转化率高达98.1%，DCBB收率为91.4%。