Among the perfluorinated substituents of organic compounds, the pentafluorosulfanyl (SF₅) group received remarkable attention in the past few decades due to its particular properties such as high thermal, chemical and metabolic stability, high density, high group electronegativity, high lipophilicity, and interesting effects on the biological activity of relevant compounds. This review retraces the massive progress made towards the preparation and application of reagents like SF₅X (X = F, Cl, Br) for the synthesis of SF₅-containing small building blocks designed for the construction of complex aliphatic molecules potentially applicable in drug and pesticide design as well as in materials sciences.

在有机化合物的全氟取代基中，五氟硫烷基（SF ₅）由于其高热、化学和代谢稳定性、高密度、高基团电负性、高亲油性和有趣的特性等特殊性质，在过去的几十年中受到了广泛关注。对相关化合物的生物活性的影响。_{本综述回顾了在制备和应用 SF 5} X (X = F, Cl, Br) 等试剂以合成含 SF ₅的小结构单元方面取得的巨大进展，这些结构单元设计用于构建可能适用于药物的复杂脂肪族分子和农药设计以及材料科学。