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pH/redox dual responsive from natural polymer-based nanoparticles for on-demand delivery of pesticides
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2022-01-25 , DOI: 10.1016/j.cej.2022.134861
Ming Zhao 1 , Peiquan Li 1 , Hongjun Zhou 1 , Li Hao 1 , Huayao Chen 1 , Xinhua Zhou 1, 2
Affiliation  

With the increase in global food demand and the destruction of environment, the development of sustainable agriculture has become increasingly more important. Stimuli-responsive controlled-release agrochemicals enhance the bioavailability of active ingredients and reduce the frequency of use and environmental pollution. Herein, 3,3′-dithiodipropionic acid was used as a functional bridge to covalently link the degradable natural polymer zein and chitosan oligosaccharides (CS) to prepare a water-dispersed environmentally friendly pesticide carrier. Subsequently, via hydrophobic and hydrogen bonding interactions photo-decomposable avermectin (AVM) was encapsulated forming a stimuli-responsive intelligent nanopesticide delivery system (AVM@CS-SS-Zein) was developed by encapsulating in the carrier. AVM was released slowly from AVM@CS-SS-Zein particles in a neutral condition and was released rapidly under stimulation of glutathione and alkalinity in simulated insects. The photostability of AVM@CS-SS-Zein was improved by 6-fold compared with that of AVM and the nanoparticles had good adherence to the leaves, slowly releasing AVM and avoiding the light decomposition of active ingredients. When the pests ingest the leaves containing AVM@CS-SS-Zein, the rapid disintegration of the nanoparticles in vivo leads to a good insecticidal effect and the control rate of AVM@CS-SS-Zein on Plutella xylostella was higher than that of AVM. After 120 h of UV irradiation, the pest mortality rate of AVM@CS-SS-Zein was 46.7% while that of AVM and AVM emulsifiable concentrate was only 13.3% and 20.0%, respectively. Therefore, this pH/redox dual stimuli-responsive nanopesticide formulation achieves target control of pests and provides an efficient nanoplatform for green agriculture.



中文翻译:

基于天然聚合物的纳米颗粒的 pH/氧化还原双重响应,用于按需输送农药

随着全球粮食需求的增加和环境的破坏,发展可持续农业变得越来越重要。刺激响应控释农用化学品可提高活性成分的生物利用度,减少使用频率和环境污染。在此,以3,3'-二硫代二丙酸为功能桥,将可降解的天然聚合物玉米醇溶蛋白和壳聚糖寡糖(CS)共价连接,制备出水分散的环保农药载体。随后,通过疏水和氢键相互作用,将光可分解​​的阿维菌素(AVM)包裹起来,形成了一种通过包裹在载体中的刺激响应智能纳米农药递送系统(AVM@CS-SS-Zein)。AVM在中性条件下从AVM@CS-SS-Zein颗粒中缓慢释放,并在模拟昆虫的谷胱甘肽和碱度刺激下迅速释放。与AVM相比,AVM@CS-SS-Zein的光稳定性提高了6倍,且纳米颗粒对叶片具有良好的附着力,缓慢释放AVM,避免了活性成分的光分解。当害虫摄入含有AVM@CS-SS-Zein的叶子时,纳米颗粒在体内的快速崩解导致了良好的杀虫效果和AVM@CS-SS-Zein的防治率。缓慢释放AVM,避免活性成分轻度分解。当害虫摄入含有AVM@CS-SS-Zein的叶子时,纳米颗粒在体内的快速崩解导致了良好的杀虫效果和AVM@CS-SS-Zein的防治率。缓慢释放AVM,避免活性成分轻度分解。当害虫摄入含有AVM@CS-SS-Zein的叶子时,纳米颗粒在体内的快速崩解导致了良好的杀虫效果和AVM@CS-SS-Zein的防治率。Plutella xylostella高于 AVM。紫外线照射120 h后,AVM@CS-SS-玉米蛋白的害虫死亡率为46.7%,而AVM和AVM乳油的死亡率分别仅为13.3%和20.0%。因此,该pH/氧化还原双重刺激响应纳米农药制剂实现了害虫的靶向防治,为绿色农业提供了高效的纳米平台。

更新日期:2022-01-30
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