Facile preparation of dihydro-1,4-benzothiazine derivatives via oxidative ring-expansion of 2-aminobenzothiazoles with olefins,Chemical Communications

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Facile preparation of dihydro-1,4-benzothiazine derivatives via oxidative ring-expansion of 2-aminobenzothiazoles with olefins
Chemical Communications ( IF 4.3 ) Pub Date : 2022-01-19 , DOI: 10.1039/d1cc06756g
Qing Sun ₁ , Xiaoguang Bao ₁

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A concise and efficient approach to prepare dihydro-1,4-benzothiazine derivatives is described via oxidative ring-expansion of 2-aminobenzothiazoles with olefins under metal-free conditions. This protocol is applicable for a wide range of readily accessible 2-aminobenzothiazoles and olefins with moderate-to-good yields. The [4+2] heteroannulation between the intermediacy of oxidative ring-opening of 2-aminobenzothiazoles and olefins is suggested to rationalize the formation of the product.

中文翻译：

2-氨基苯并噻唑与烯烃氧化扩环制备二氢-1,4-苯并噻嗪衍生物

描述了一种在无金属条件下通过2-氨基苯并噻唑与烯烃的氧化扩环制备二氢 1,4-苯并噻嗪衍生物的简洁有效的方法。该协议适用于各种容易获得的 2-氨基苯并噻唑和烯烃，产率中等至良好。建议 2-氨基苯并噻唑和烯烃的氧化开环中间体之间的 [4+2] 杂环化使产物的形成合理化。

更新日期：2022-01-19

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