In this article, the effect of mesoporous silica (MS) on the physical stability and molecular dynamics of the amorphous form of Celecoxib (CEL) is investigated. It has been proven that the recrystallization process of CEL slows down with increasing the MS content. Beside the elongation of stabilization time with the increase silica content leads to an increase in the amorphous drug fraction remaining after the finished crystallization. The conducted analyses show that the observed inhibition of CEL's recrystallization is associated with the formation of a monomolecular drug layer on the silica's surface. The performed non-isothermal dielectric studies of CEL + MS systems having both fully and partially amorphous CEL shows that the biggest impact of the drug's the temperature dependences of structural relaxation time τ_α(T) has a crystalline fraction of the API. Silica, even in high concentration, does not modify the temperature dependence of structural relaxation of CEL.

本文研究了介孔二氧化硅 (MS) 对无定形塞来昔布 (CEL) 的物理稳定性和分子动力学的影响。已经证明，CEL的再结晶过程随着MS含量的增加而减慢。除了随着二氧化硅含量的增加而延长稳定时间之外，还导致完成结晶后剩余的无定形药物部分增加。进行的分析表明，观察到的 CEL 重结晶抑制与二氧化硅表面上单分子药物层的形成有关。对具有完全和部分无定形 CEL 的 CEL + MS 系统进行的非等温介电研究表明，药物的最大影响_α (T)具有 API 的结晶部分。二氧化硅，即使在高浓度下，也不会改变 CEL 结构弛豫的温度依赖性。