Indole-3-Propionic Acid（一种肠道微生物衍生代谢物）及其前体色氨酸在哺乳动物健康和疾病中的生物学作用,International Journal of Molecular Sciences

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Indole-3-Propionic Acid（一种肠道微生物衍生代谢物）及其前体色氨酸在哺乳动物健康和疾病中的生物学作用
International Journal of Molecular Sciences ( IF 4.9 ) Pub Date : 2022-01-24 , DOI: 10.3390/ijms23031222
Piotr Konopelski ₁ , Izabella Mogilnicka ₁

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共生肠道微生物群的作用与宿主的有机体保持动态平衡，以维持体内平衡。许多不同的因素都会影响这种关系，包括细菌代谢物。已经建立了几种合成它们的底物，包括色氨酸，一种外源氨基酸。许多生物过程受到色氨酸及其内源性代谢物、血清素和褪黑激素的作用。最近的研究结果还提供了证据，表明肠道细菌衍生的色氨酸代谢物具有其前体的生物学效应。因此，本综述旨在研究吲哚-3-丙酸 (IPA) 的生物学作用，IPA 是一种肠道微生物群衍生的色氨酸代谢物。我们搜索了 PUBMED 和 Google Scholar 数据库，以确定评估 IPA 对哺乳动物免疫、神经、胃肠道和心血管系统的健康和病理生理学影响的临床前和临床研究。IPA 对能量平衡和心血管系统的影响与其前体色氨酸相似。此外，IPA 通过防止氧化应激损伤、脂质过氧化和抑制促炎细胞因子的合成，对细胞水平产生积极影响。在存在不同的动脉粥样硬化危险因素的情况下，其合成可能会减少。另一方面，保护因素，例如引入地中海饮食，往往会增加其血浆浓度。IPA 似乎是一个很有前途的新目标，它将肠道健康与心血管系统联系起来。

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Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites. Several substrates for their synthesis have been established, including tryptophan, an exogenous amino acid. Many biological processes are influenced by the action of tryptophan and its endogenous metabolites, serotonin, and melatonin. Recent research findings also provide evidence that gut bacteria-derived metabolites of tryptophan share the biological effects of their precursor. Thus, this review aims to investigate the biological actions of indole-3-propionic acid (IPA), a gut microbiota-derived metabolite of tryptophan. We searched PUBMED and Google Scholar databases to identify pre-clinical and clinical studies evaluating the impact of IPA on the health and pathophysiology of the immune, nervous, gastrointestinal and cardiovascular system in mammals. IPA exhibits a similar impact on the energetic balance and cardiovascular system to its precursor, tryptophan. Additionally, IPA has a positive impact on a cellular level, by preventing oxidative stress injury, lipoperoxidation and inhibiting synthesis of proinflammatory cytokines. Its synthesis can be diminished in the presence of different risk factors of atherosclerosis. On the other hand, protective factors, such as the introduction of a Mediterranean diet, tend to increase its plasma concentration. IPA seems to be a promising new target, linking gut health with the cardiovascular system.

更新日期：2022-01-24

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