In this work, we construct the Bi₂O₂X/SrTiO₃ heterostructures and explore the geometric, electronic, optical, and transport characteristics based on density functional theory (DFT) in integration with non-equilibrium Green's function (NEGF) calculations. The influence of chalcogen elements on the Bi₂O₂X/SrTiO₃ interface is discussed. Eighteen different interface configurations with different terminations are designed and the most stable configurations are determined. The interfaces between SrO-terminated SrTiO₃ and O-terminated Bi₂O₂X show the highest cohesive energy and strongest charge interaction regardless of the chalcogen elements, which is the best interfacial stability. Among these interfaces, the Bi₂O₂S/SrTiO₃ interface were found to possess the largest cohesive energy and best stability due to the fewer and lower surface states around the Fermi level. By contrast, the Bi₂O₂Te/SrTiO₃ interface shows the largest dielectric function among these three interfacial systems leading to better optical property. In addition, the electronic transport properties reveal that Bi₂O₂Te/SrTiO₃ has the largest transmission coefficient indicates enhanced electron transport and electric current at the interface.