MicroProteins: Dynamic and accurate regulation of protein activity,Journal of Integrative Plant Biology

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MicroProteins: Dynamic and accurate regulation of protein activity
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2022-01-20 , DOI: 10.1111/jipb.13229
Qingqing Wu _{1,

2,

3} , Shangwei Zhong ₂ , Hui Shi ₁

Affiliation

Proteins usually assemble oligomers or high-order complexes to increase their efficiency and specificity in biological processes. The dynamic equilibrium of complex formation and disruption imposes reversible regulation of protein function. MicroProteins are small, single-domain proteins that directly bind target protein complexes and disrupt their assembly. Growing evidence shows that microProteins are efficient regulators of protein activity at the post-translational level. In the last few decades, thousands of plant microProteins have been predicted by computational approaches, but only a few have been experimentally validated. Recent studies highlighted the mechanistic working modes of newly-identified microProteins in Arabidopsis and other plant species. Here, we review characterized microProteins, including their biological roles, regulatory targets, and modes of action. In particular, we focus on microProtein-directed allosteric modulation of key components in light signaling pathways, and we summarize the biogenesis and evolutionary trajectory of known microProteins in plants. Understanding the regulatory mechanisms of microProteins is an important step towards potential utilization of microProteins as versatile biotechnological tools in crop bioengineering.

中文翻译：

MicroProteins：蛋白质活性的动态和准确调节

蛋白质通常组装寡聚体或高级复合物以提高其在生物过程中的效率和特异性。复合物形成和破坏的动态平衡强加了蛋白质功能的可逆调节。微蛋白是小的单域蛋白，可直接结合靶蛋白复合物并破坏它们的组装。越来越多的证据表明，微蛋白质是翻译后水平蛋白质活性的有效调节剂。在过去的几十年里，通过计算方法预测了数千种植物微蛋白，但只有少数得到了实验验证。最近的研究强调了拟南芥中新发现的微蛋白的机制工作模式和其他植物种类。在这里，我们回顾了特征微蛋白，包括它们的生物学作用、调控目标和作用方式。特别是，我们专注于光信号通路中关键成分的微蛋白定向变构调节，并总结了植物中已知微蛋白的生物发生和进化轨迹。了解微蛋白的调控机制是迈向潜在利用微蛋白作为作物生物工程中的多功能生物技术工具的重要一步。

更新日期：2022-01-20

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