The use of gesture control has numerous advantages compared to the use of physical hardware. However, it has yet to gain popularity as most gesture control systems require extra sensors or depth cameras to detect or capture the movement of gestures before a meaningful signal can be triggered for corresponding course of action. This research proposes a method for a hand gesture control system with the use of an object detection algorithm, YOLOv3, combined with handcrafted rules to achieve dynamic gesture control on the computer. This project utilizes a single RGB camera for hand gesture recognition and localization. The dataset of all gestures used for training and its corresponding commands, are custom designed by the authors due to the lack of standard gestures specifically for human–computer interaction. Algorithms to integrate gesture commands with virtual mouse and keyboard input through the Pynput library in Python, were developed to handle commands such as mouse control, media control, and others. The mAP result of the YOLOv3 model obtained 96.68% accuracy based on testing result. The use of rule-based algorithms for gesture interpretation was successfully implemented to transform static gesture recognition into dynamic gesture.