The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation of rabbit platelets. Benzofuran neolignans were found to be selective COX-2 inhibitors, whereas bicyclooctane neolignans inhibit selectively the PAF-action as well as COX-1 and 5-LOX. The neolignan 9-nor-7,8-dehydro-isolicarin B 15 and cinerin C 7 were found to be the most potent COX-2 inhibitor and PAF-antagonist, respectively. Nectamazin C 10 exhibited dual 5-LOX/COX-2 inhibition.

26个新木脂体的抗炎电位（二环型14和苯并呋喃型的12），从三个樟科物种（隔绝Pleurothyrium cinereum，Ocotea艽和Nectandra amazonum），在体外通过抑制COX-1的评价，COX-2、5-LOX和激动剂诱导的兔血小板聚集。发现苯并呋喃新木脂素是选择性的COX-2抑制剂，而双环辛烷新木脂素选择性地抑制PAF作用以及COX-1和5-LOX。发现新木脂体9-或-7,8-脱氢-异水杨苷B 15和电影蛋白C 7分别是最有效的COX-2抑制剂和PAF拮抗剂。油桃素C 10 表现出双重5-LOX / COX-2抑制作用。