Metal-free bioorthogonal click chemistry in cancer theranostics,Chemical Society Reviews

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Metal-free bioorthogonal click chemistry in cancer theranostics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-01-20 , DOI: 10.1039/d1cs00451d
Dan Wu ₁ , Kuikun Yang ₂ , Zhankui Zhang ₁ , Yunxuan Feng ₃ , Lang Rao ₄ , Xiaoyuan Chen ₅ , Guocan Yu ₃

Affiliation

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems. Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and specifically take place in a mild physiological milieu without perturbing inherent biochemical processes. Attributed to their high selectivity and efficiency, bioorthogonal reactions can significantly decrease background signals in bioimaging. Compared with metal-catalyzed bioorthogonal click reactions, metal-free click reactions are more biocompatible without the metal catalyst-induced cytotoxicity. Although a great number of bioorthogonal chemistry-based strategies have been reported for cancer theranostics, a comprehensive review is scarce to highlight the advantages of these strategies. In this review, recent progress in cancer theranostics guided by metal-free bioorthogonal click chemistry will be depicted in detail. The elaborate design as well as the advantages of bioorthogonal chemistry in tumor theranostics are summarized and future prospects in this emerging field are emphasized.

中文翻译：

癌症治疗学中的无金属生物正交点击化学

生物正交化学是一种强大的工具，可以在生命系统中特异性地激活药物。一对生物反应基团之间的生物正交反应可以在温和的生理环境中快速且特异性地发生，而不会干扰固有的生化过程。由于其高选择性和效率，生物正交反应可以显着降低生物成像中的背景信号。与金属催化的生物正交点击反应相比，无金属点击反应更具生物相容性，没有金属催化剂诱导的细胞毒性。尽管已经报道了大量基于生物正交化学的癌症治疗学策略，但很少有全面的综述来突出这些策略的优势。在本次审查中，将详细描述以无金属生物正交点击化学为指导的癌症治疗学的最新进展。总结了生物正交化学在肿瘤治疗学中的精心设计和优势，并强调了这一新兴领域的未来前景。

更新日期：2022-01-20

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