甲醇、乙醇、异丙醇和乙二醇等水性助溶剂中莫昔克丁溶解度的测定及相关性,Journal of Chemical & Engineering Data

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甲醇、乙醇、异丙醇和乙二醇等水性助溶剂中莫昔克丁溶解度的测定及相关性
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2022-01-20 , DOI: 10.1021/acs.jced.1c00517
Chunjuan Huang ₁ , Renjie Xu ₁

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在这项研究中，在 278.15–323.15 K 的研究温度下，通过重量法测定了莫西克丁在甲醇 + 水、乙醇 + 水、异丙醇 + 水和乙二醇 (EG) + 水四种水性共溶剂混合物中的溶解度。低于 101.2 kPa。所有助溶剂（甲醇、乙醇、异丙醇、EG）均表现出良好的溶解能力，在溶解度的摩尔分数尺度上溶解度由高到低的顺序为：乙醇（0.2229、323.15 K）>甲醇（0.1053、323.15） K) > 异丙醇 (4.552 × 10 ^–2 , 323.15 K) > EG (2.103 × 10 ^–2 , 323.15 K) > 水 (2.491 × 10 ^–5, 323.15 K)。从温度和助溶剂质量分数获得的数据中，发现莫西克丁溶解度值在乙醇 + 水系统中比在其他系统中最大。通过 X 射线粉末衍射对莫西克丁的平衡固体进行了表征，表明在整个实验过程中不存在溶剂化物形成和晶体转变。测量的溶解度值通过三个模型进行定量计算和数学关联；综上所述，得到的相对平均偏差和均方根偏差分别不高于5.81%和1.556 × 10 ^–3。

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Determination and Correlation of Moxidectin Solubility in Aqueous Cosolvents of Methanol, Ethanol, Isopropanol, and Ethylene Glycol

In this study, the moxidectin solubility in four kinds of aqueous cosolvent mixtures of methanol + water, ethanol + water, isopropanol + water, and ethylene glycol (EG) + water was determined by the gravimetric method at the investigated temperatures of 278.15–323.15 K under 101.2 kPa. All cosolvents (methanol, ethanol, isopropanol, and EG) displayed good dissolving capability, and the order of solubility from high to low in the mole fraction scale of solubility is as follows: ethanol (0.2229, 323.15 K) > methanol (0.1053, 323.15 K) > isopropanol (4.552 × 10^–2, 323.15 K) > EG (2.103 × 10^–2, 323.15 K) > water (2.491 × 10^–5, 323.15 K). From the data obtained for temperature and cosolvent mass fractions, the moxidectin solubility values were found to be the largest in the ethanol + water system than in the other systems. The equilibrated solids of moxidectin were characterized by X-ray powder diffraction, revealing the absence of solvate formation and crystal transition during the entire experiments. The measured solubility values were quantitatively calculated and correlated mathematically by three models; in conclusion, the obtained values of relative average deviation and root-mean-square deviation were not higher than 5.81% and 1.556 × 10^–3, respectively.

更新日期：2022-02-10

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