Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy,ACS Applied Materials & Interfaces

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Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-01-20 , DOI: 10.1021/acsami.1c19985
Yan Song ₁ , Yuan Sun ₂ , Minglu Tang ₁ , Zhengya Yue ₁ , Jiatong Ni ₁ , Junge Zhao ₁ , Wenxin Wang ₁ , Tiedong Sun ₁ , Lianxu Shi ₁ , Lei Wang ₃

Affiliation

Electrodynamic therapy (EDT) and chemodynamic therapy (CDT) have the potential for future tumor treatment; however, their underlying applications are greatly hindered owing to their inherent drawbacks. The combination of EDT and CDT has been considered to be an effective way to maximize the superiorities of these two ROS-based methodologies. However, the development of novel nanomaterials with “one-for-all” functions still remains a big challenge. In this work, the polyoxometalate nanoparticles (NPs) were decorated using the zeolite imidazole framework (POM@ZIF-8) in order to integrate the EDT with CDT. The resulting POM@ZIF-8 NPs can effectively induce the generation of reactive oxygen species (ROS) via a catalytic reaction on the surface of POM NPs induced by an electric field (E). At the same time, POM@ZIF-8 NPs can catalyze the intracellular H₂O₂ into ROS via a Fenton-like reaction, thereby achieving the combination of EDT and CDT. Besides, since ZIF-8 is acid-responsive, it can protect normal tissues and avoid side effects. Of great note is that the cytotoxicity and the apoptosis rate of the POM@ZIF-8+E group (80%) were found to be significantly higher than that of the E group (55%). As a result, a high tumor inhibition phenomenon can be observed both in vitro and in vivo. The present study thus provides an alternative concept for combinational therapeutic modality with exceptional efficacy.

中文翻译：

沸石咪唑骨架修饰的多金属氧酸盐用于 pH 响应的电动/化学动力学治疗

电动力学疗法（EDT）和化学动力学疗法（CDT）具有未来肿瘤治疗的潜力；然而，由于其固有的缺点，它们的基础应用受到了很大的阻碍。EDT 和 CDT 的结合被认为是最大限度地发挥这两种基于 ROS 的方法的优势的有效方法。然而，开发具有“一体式”功能的新型纳米材料仍然是一个巨大的挑战。在这项工作中，使用沸石咪唑骨架（POM@ZIF-8）修饰多金属氧酸盐纳米颗粒（NP），以将 EDT 与 CDT 集成。由此产生的 POM@ZIF-8 NPs 可以通过以下途径有效诱导活性氧 (ROS) 的产生由电场 (E) 诱导的 POM NPs 表面上的催化反应。同时，POM@ZIF-8 NPs可以通过类芬顿反应催化细胞内H ₂ O ₂转化为ROS ，从而实现EDT和CDT的结合。此外，由于 ZIF-8 对酸有反应，因此可以保护正常组织，避免副作用。值得注意的是，发现POM@ZIF-8+E组的细胞毒性和细胞凋亡率（80%）明显高于E组（55%）。结果，在体外和体内都可以观察到高度的肿瘤抑制现象。因此，本研究为具有卓越疗效的联合治疗方式提供了另一种概念。

更新日期：2022-02-02

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