4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BDPI)-Triphenylphosphine Nanoparticles as a Photodynamic Antibacterial Agent,ACS Applied Nano Materials

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4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BDPI)-Triphenylphosphine Nanoparticles as a Photodynamic Antibacterial Agent
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-01-18 , DOI: 10.1021/acsanm.1c04143
Hui Wen _{1,

2} , Qihang Wu _{1,

2} , Chaonan Li _{1,

2} , Tingting Sun ₁ , Zhigang Xie _{1,

2}

Affiliation

Photodynamic therapy (PDT) has aroused great interest in antimicrobial treatment because it can take advantage of the reactive oxygen species (ROS) generated by photosensitizers under laser irradiation to kill bacteria efficiently without causing drug resistance. Herein, we designed a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) photosensitizer (BDPI-TPP) with a triphenylphosphine (TPP) cation for highly efficient PDT against bacteria. The prepared BDPI-TPP nanoparticles (BDPI-TPP NPs) can adhere to the surface of bacteria via electrostatic interactions between the positively charged BDPI-TPP NPs and the negatively charged bacterial membranes. More importantly, BDPI-TPP NPs exhibit a potent antibacterial effect with a small minimum inhibitory concentration (MIC) of only 0.3 μg mL^–1 attributing to both the positive charges and the photodynamic activity. What is more, BDPI-TPP NPs can also damage the preformed biofilm and effectively promote wound healing. This work highlights the potential of designing cationic photosensitizers as highly efficient antimicrobial agents.

中文翻译：

4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BDPI)-Triphenylphosphine Nanoparticles 作为光动力抗菌剂

光动力疗法 (PDT) 引起了人们对抗菌治疗的极大兴趣，因为它可以利用光敏剂在激光照射下产生的活性氧 (ROS) 在不引起耐药性的情况下有效杀死细菌。在此，我们设计了一种具有三苯膦 (TPP) 阳离子的 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) 光敏剂 (BDPI-TPP)，用于高效的 PDT 对抗细菌。制备的 BDPI-TPP 纳米颗粒 (BDPI-TPP NPs) 可以通过带正电的 BDPI-TPP NPs 和带负电的细菌膜之间的静电相互作用粘附在细菌表面。更重要的是，BDPI-TPP NPs 表现出强大的抗菌作用，最低抑菌浓度 (MIC) 仅为 0.3 μg mL ^–1归因于正电荷和光动力活动。更重要的是，BDPI-TPP NPs还可以破坏预先形成的生物膜，有效促进伤口愈合。这项工作突出了将阳离子光敏剂设计为高效抗菌剂的潜力。

更新日期：2022-01-28

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