Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate,Molecular Pharmaceutics

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Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2022-01-19 , DOI: 10.1021/acs.molpharmaceut.1c00668
Michela Beretta _{1,

2} , Joana T Pinto ₁ , Peter Laggner ₁ , Amrit Paudel _{1,

2}

Affiliation

The impact of the crystallinity of organic solid materials on their tribocharging propensity is well reported. However, no unequivocal explanation about the potential underlying mechanism(s) could be found so far in the literature. This study reports the effect that different degrees of crystalline disorder has on the tribocharging propensity of a small molecular organic material, salbutamol sulfate (SS). Ball-milling was used to induce structural transformations in the crystalline structure of SS. Particles with different nanostructures were produced and analyzed for their solid-state, particle properties, and tribocharging. It was found that differences in the amorphous content among the processed particles and related moisture levels had an impact on powder tribocharging. A correlation between the latter and the nanostructural properties of the particles was also established. The presence of interfaces between nanodomains of different densities and shorter average lengths within the phases seems to lead to a mitigation of charge. This suggests that undetected, subtle nanostructural differences of materials can affect powder handling and processability by altering their tribocharging. The present findings demonstrate the nanostructural implications of powder triboelectrification, which can help toward the rational design of a wide variety of organic solids.

中文翻译：

深入了解纳米结构特性对粉末摩擦充电的影响：以研磨的沙丁胺醇硫酸盐为例

有机固体材料的结晶度对其摩擦带电倾向的影响已得到充分报道。然而，到目前为止，在文献中还没有找到关于潜在潜在机制的明确解释。本研究报告了不同程度的结晶紊乱对小分子有机材料硫酸沙丁胺醇 (SS) 的摩擦带电倾向的影响。球磨用于诱导 SS 晶体结构的结构转变。生产了具有不同纳米结构的颗粒并分析了它们的固态、颗粒特性和摩擦带电。研究发现，加工颗粒之间无定形含量的差异和相关的水分含量对粉末摩擦带电有影响。还建立了后者与颗粒的纳米结构特性之间的相关性。相内不同密度的纳米域和较短的平均长度之间存在界面似乎导致电荷的减轻。这表明，未检测到的、细微的材料纳米结构差异会通过改变它们的摩擦充电来影响粉末的处理和加工性能。目前的研究结果证明了粉末摩擦起电的纳米结构意义，这有助于合理设计各种有机固体。材料的细微纳米结构差异可以通过改变它们的摩擦充电来影响粉末的处理和加工性能。目前的研究结果证明了粉末摩擦起电的纳米结构意义，这有助于合理设计各种有机固体。材料的细微纳米结构差异可以通过改变它们的摩擦充电来影响粉末的处理和加工性能。目前的研究结果证明了粉末摩擦起电的纳米结构意义，这有助于合理设计各种有机固体。

更新日期：2022-02-07

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