Evodiamine is a natural alkaloid extracted from Fructus Evodia. This bioactive alkaloid has been reported to have a wide range of biological activities, including anti-injury, antiobesity, vasodilator, and anti-inflammatory effects. In recent years, it has been found that evodiamine has tumor-suppressive effects on a variety of tumors. There is growing evidence that evodiamine can inhibit the rapid proliferation of tumor cells, induce cell cycle arrest at a certain phase, increase the incidence of apoptosis, promote autophagy, inhibit microangiogenesis and migration, and regulate immunotherapy. Evodiamine can inhibit Wnt/β-catenin, mTOR, NF-κB, PI3K/AKT, JAK-STAT, and other signaling pathways in various cancer cells, and it can significantly downregulate the expression of many tumor markers, such as VEGF and COX-2. These facts partially explain the antitumor mechanism of evodiamine. In this article, the antitumor mechanism of evodiamine was reviewed to provide the basis for its clinical application and therapeutic development in the future.

中文翻译：

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吴茱萸碱抗肿瘤机制研究进展

吴茱萸碱是从吴茱萸中提取的天然生物碱。据报道，这种生物活性生物碱具有广泛的生物活性，包括抗损伤、抗肥胖、血管扩张和抗炎作用。近年来发现吴茱萸碱对多种肿瘤具有抑瘤作用。越来越多的证据表明吴茱萸碱可以抑制肿瘤细胞的快速增殖，诱导细胞周期停滞在某个阶段，增加细胞凋亡的发生率，促进自噬，抑制微血管生成和迁移，调节免疫治疗。吴茱萸碱可抑制 Wnt/ β -catenin、mTOR、NF- κB、PI3K/AKT、JAK-STAT等多种癌细胞中的信号通路，可显着下调VEGF、COX-2等多种肿瘤标志物的表达。这些事实部分解释了吴茱萸碱的抗肿瘤机制。本文就吴茱萸碱的抗肿瘤作用机制进行综述，为其今后的临床应用和治疗发展提供依据。