Catalytic Enantioconvergent Allenylation of Aldehydes with Propargyl Halides,Angewandte Chemie International Edition

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Catalytic Enantioconvergent Allenylation of Aldehydes with Propargyl Halides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-01-13 , DOI: 10.1002/anie.202117114
Feng-Hua Zhang _{1,

2} , Xiaochong Guo _{1,

2} , Xianrong Zeng _{1,

2} , Zhaobin Wang _{1,

2}

Affiliation

A Cr-catalyzed enantioconvergent allenylation reaction of aldehydes with racemic propargyl halides has been developed. This robust method employs simple and readily accessible materials, exhibits exceptional functional group tolerance and broad substrate scope, and provides facile access to a wide range of valuable optically enriched α-allenols with two or three continuous chiral centers, including both central and axial chirality.

中文翻译：

炔丙基卤化物催化醛的对映收敛烯基化反应

已经开发了 Cr 催化的醛与外消旋炔丙基卤化物的对映收敛烯基化反应。这种稳健的方法采用简单且易于获得的材料，具有出色的官能团耐受性和广泛的底物范围，并提供了对具有两个或三个连续手性中心（包括中心手性和轴向手性）的各种有价值的光学富集的 α-丙二烯醇的轻松访问。

更新日期：2022-01-13

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