Heritability of tea drinking and its relationship with cigarette smoking in the Chinese male adult twins,Addiction Biology

当前位置： X-MOL 学术 › Addict. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Heritability of tea drinking and its relationship with cigarette smoking in the Chinese male adult twins
Addiction Biology ( IF 3.1 ) Pub Date : 2022-01-13 , DOI: 10.1111/adb.13129
Wang Dongmeng ₁ , Xi Yu'e ₁ , Gao Wenjing ₁ , Zheng Ke ₁ , Lv Jun ₁ , Yu Canqing ₁ , Wang Shengfeng ₁ , Huang Tao ₁ , Sun Dianjianyi ₁ , Liao Chunxiao ₁ , Pang Yuanjie ₁ , Pang Zengchang ₂ , Yu Min ₃ , Wang Hua ₄ , Wu Xianping ₅ , Dong Zhong ₆ , Wu Fan ₇ , Jiang Guohong ₈ , Wang Xiaojie ₉ , Liu Yu ₁₀ , Deng Jian ₁₁ , Lu Lin ₁₂ , Cao Weihua ₁ , Li Liming ₁

Affiliation

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Sichuan Center for Disease Control and Prevention, Chengdu, China.
Beijing Center for Disease Prevention and Control, Beijing, China.
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Tianjin Centers for Disease Control and Prevention, Tianjin, China.
Qinghai Center for Diseases Prevention and Control, Xining, China.
Heilongjiang Provincial Center for Disease Control and Prevention, Harbin, China.
Handan Center for Disease Control and Prevention, Handan, China.
Yunnan Center for Disease Control and Prevention, Kunming, China.

The aims of this study are to estimate the contributions of genetic factors to the variation of tea drinking and cigarette smoking, to examine the roles of genetic factors in their correlation and further to investigate underlying causation between them. We included 11 625 male twin pairs from the Chinese National Twin Registry (CNTR). Bivariate genetic modelling was fitted to explore the genetic influences on tea drinking, cigarette smoking and their correlation. Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) was further used to explore the causal relationship between them. We found that genetic factors explained 17% and 23% of the variation in tea drinking and cigarette smoking, respectively. A low phenotypic association between them was reported (r_ph = 0.21, 95% confidence interval [CI]: [0.19, 0.24]), which was partly attributed to common genetic factors (r_A = 0.45, 95% CI [0.19, 1.00]). In the ICE FALCON analysis with current smoking as the exposure, tea drinking was associated with his own (βself = 0.39, 95% CI [0.23, 0.55]) and his co-twin's smoking status (βco-twin = 0.25, 95% CI [0.10, 0.41]). Their association attenuated with borderline significance conditioning on his own smoking status (p = 0.045), indicating a suggestive causal effect of smoking status on tea drinking. On the contrary, when we used tea drinking as the predictor, we found familial confounding between them only. In conclusion, both tea drinking and cigarette smoking were influenced by genetic factors, and their correlation was partly explained by common genetic factors. In addition, our finding suggests that familial confounders account for the relationship between tea drinking and cigarette smoking. And current smoking might have a causal effect on weekly tea drinking, but not vice versa.

更新日期：2022-02-10

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南