Bionic Dormant Body of Timed Wake-Up for Bacteriotherapy in Vivo,ACS Nano

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Bionic Dormant Body of Timed Wake-Up for Bacteriotherapy in Vivo
ACS Nano ( IF 15.8 ) Pub Date : 2022-01-13 , DOI: 10.1021/acsnano.1c08377
Mingming Guo ₁ , Chunrui Yang _{1,

2} , Bowen Li ₁ , Shi-Xiang Cheng _{1,

3} , Qinglu Guo ₁ , Dong Ming ₁ , Bin Zheng _{1,

3,

4}

Affiliation

The microorganism has become a promising therapeutic tool for many diseases because it is a kind of cell factory that can efficiently synthesize a variety of bioactive substances. However, the metabolic destiny of microorganisms is difficult to predict in vivo. Here, a timing bionic dormant body with programmable destiny is reported, which can predict the metabolic time and location of microorganisms in vivo and can prevent it from being damaged by the complex biological environment in vivo. Taking the complex digestive system as an example, the bionic dormant body exists in the upper digestive tract as a nonmetabolic dormant body after oral administration and will be awakened to synthesize bioactive substances about 2 h after reaching the intestine. Compared with oral microorganisms alone, the bioavailability of the biomimetic dormant body in the intestine is almost 3.5 times higher. The utilization rate of the oral bionic dormant body to synthesize drugs is 2.28 times higher than oral drugs. We demonstrated the significant efficacies of treatment using Parkinson’s disease (PD) mice by dormant body capable of timed neurotransmitter production after oral delivery. The timed bionic dormant body with programmable destiny may provide an effective technology to generate advanced microbial therapies for the treatment of various diseases.

中文翻译：

用于体内细菌治疗的定时唤醒仿生休眠体

由于微生物是一种能够高效合成多种生物活性物质的细胞工厂，因此微生物已成为许多疾病的有前途的治疗工具。然而，微生物的代谢命运在体内很难预测。在此，报道了一种具有可编程命运的定时仿生休眠体，它可以预测微生物在体内的代谢时间和位置，并可以防止其被体内复杂的生物环境破坏. 以复杂的消化系统为例，仿生休眠体口服后以非代谢休眠体的形式存在于上消化道，到达肠道约2 h后被唤醒合成生物活性物质。与单独使用口腔微生物相比，仿生休眠体在肠道内的生物利用度几乎高出3.5倍。口服仿生休眠体合成药物的利用率是口服药物的2.28倍。我们通过能够在口服给药后定时产生神经递质的休眠体，证明了使用帕金森病 (PD) 小鼠进行治疗的显着疗效。具有可编程命运的定时仿生休眠体可以提供一种有效的技术来产生用于治疗各种疾病的先进微生物疗法。

更新日期：2022-01-25

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