Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules on top of the nanotube surface by using cyclic peptides bearing chemoreversible reactive groups. D,L-α-Cyclic peptides endowed with a hydrazide moiety were condensed with a pyrenecarboxyaldehyde to facilitate the nanotube formation and deposition on flat unfunctionalized surfaces. The hydrazide moieties can be liberated without affecting the tubular structure and then used to align on top of the nanotube other molecules bearing aldehyde functions. Additionally, the attachment of specific ligands allowed the supramolecular alignment of corresponding receptors, such as mannosyl aldehyde and concavaline-A, driven by the nanotube structure through complemetary protein–ligand interactions.

中文翻译：

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通过使用环状肽纳米管上的可逆共价键对蛋白质和其他纳米颗粒进行一维排列

自组装环肽纳米管是一种超分子结构，其直径和外表面性质得到精确控制。在本次交流中，我们描述了一种通用策略，通过使用带有化学可逆反应基团的环肽来排列纳米管表面上的不同分子。, L _具有酰肼部分的-α-环肽与芘羧醛缩合，以促进纳米管的形成和沉积在平坦的非功能化表面上。可以在不影响管状结构的情况下释放酰肼部分，然后用于在纳米管顶部排列其他带有醛功能的分子。此外，特定配体的附着允许相应受体的超分子排列，例如甘露糖醛和刀豆碱-A，由纳米管结构通过互补的蛋白质-配体相互作用驱动。