Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model,MicrobiologyOpen

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Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2022-01-13 , DOI: 10.1002/mbo3.1257
Sarah Fink ₁ , Anke Burmester ₁ , Uta-Christina Hipler ₁ , Claudia Neumeister ₂ , Marcus R Götz ₂ , Cornelia Wiegand ₁

Affiliation

Dermal fungal infections have increased over recent years. This study aimed to investigate the sporicidal effects of antimycotics using microplate laser nephelometry and infected three-dimensional full skin models. Sertaconazole nitrate inhibited the growth of dermatophytes, molds, and yeasts. Ciclopirox olamine also had antifungal activity, although, higher concentrations were needed compared to sertaconazole nitrate. Terbinafine was highly effective against most dermatophytes, but higher concentrations were required to kill the resistant strain of Trichophyton indotineae.

中文翻译：

抗真菌药物对抗真菌孢子的功效：使用微孔板激光比浊法和人工感染 3D 皮肤模型进行的体外研究

近年来，皮肤真菌感染有所增加。本研究旨在利用微板激光比浊法和感染的三维全皮肤模型研究抗真菌药的杀孢子作用。硝酸舍他康唑抑制皮肤癣菌、霉菌和酵母菌的生长。环吡酮乙醇胺也具有抗真菌活性，但与硝酸舍他康唑相比需要更高的浓度。特比萘芬对大多数皮肤癣菌非常有效，但需要更高的浓度才能杀死吲哚毛癣菌的耐药菌株。

更新日期：2022-02-11

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