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Truly Multicolor Emissive Hyperbranched Polysiloxane: Synthesis, Mechanism Study, and Visualization of Controlled Drug Release
Biomacromolecules ( IF 5.5 ) Pub Date : 2022-01-11 , DOI: 10.1021/acs.biomac.1c01396 Lihua Bai 1, 2 , Pengfei Yang 1 , Liulong Guo 1 , Susu Liu 1 , Hongxia Yan 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2022-01-11 , DOI: 10.1021/acs.biomac.1c01396 Lihua Bai 1, 2 , Pengfei Yang 1 , Liulong Guo 1 , Susu Liu 1 , Hongxia Yan 1
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Unconventional fluorescent polymers have attracted increasing attention due to their facile synthesis, excellent biocompatibility, and novel photophysical properties. In this work, a truly multicolor emissive hyperbranched polysiloxane (HBPSi-β-CD) is obtained through adjusting the distribution of electron-rich atoms and grafting β-cyclodextrin; the quantum yields of HBPSi-β-CD after being excited by 360, 420, 450, and 550 nm are 19.36, 31.46, 46.14 and 44.84%, respectively. The density functional theory calculations reveal that the truly multicolor emission is derived from the formed electron delocalization among the hydroxyl, amine, ether, and −Si(O)3 groups due to the strong intermolecular interaction, high density of electron-rich atoms, and low steric hindrance among functional groups. The prepared polymers could serve as a multisensitivity sensor in detecting Fe3+, Cu2+, and Co2+. The HBPSi-β-CD shows low cytotoxicity and excellent cellular imaging capability. The self-assembly of HBPSi-β-CD also possesses high drug loading capacity and pH-controlled drug release, especially, the drug delivery system could be applied in the visualization of controlled drug delivery.
中文翻译：
真正的多色发光超支化聚硅氧烷：受控药物释放的合成、机理研究和可视化
非常规荧光聚合物由于其易于合成、优异的生物相容性和新颖的光物理性质而引起了越来越多的关注。本工作通过调节富电子原子分布和接枝β-环糊精获得了真正的多色发光超支化聚硅氧烷（HBPSi-β-CD）；HBPSi-β-CD在360、420、450和550 nm激发后的量子产率分别为19.36、31.46、46.14和44.84%。密度泛函理论计算表明，真正的多色发射源自羟基、胺、醚和-Si(O) 3之间形成的电子离域由于分子间相互作用强，富电子原子密度高，官能团之间的空间位阻低。所制备的聚合物可用作检测Fe 3+、Cu 2+和Co 2+的多灵敏度传感器。HBPSi-β-CD 显示出低细胞毒性和出色的细胞成像能力。HBPSi-β-CD的自组装还具有较高的载药能力和pH可控的药物释放，特别是该药物递送系统可应用于可控药物递送的可视化。
更新日期：2022-01-11
中文翻译：
真正的多色发光超支化聚硅氧烷：受控药物释放的合成、机理研究和可视化
非常规荧光聚合物由于其易于合成、优异的生物相容性和新颖的光物理性质而引起了越来越多的关注。本工作通过调节富电子原子分布和接枝β-环糊精获得了真正的多色发光超支化聚硅氧烷（HBPSi-β-CD）；HBPSi-β-CD在360、420、450和550 nm激发后的量子产率分别为19.36、31.46、46.14和44.84%。密度泛函理论计算表明，真正的多色发射源自羟基、胺、醚和-Si(O) 3之间形成的电子离域由于分子间相互作用强，富电子原子密度高，官能团之间的空间位阻低。所制备的聚合物可用作检测Fe 3+、Cu 2+和Co 2+的多灵敏度传感器。HBPSi-β-CD 显示出低细胞毒性和出色的细胞成像能力。HBPSi-β-CD的自组装还具有较高的载药能力和pH可控的药物释放，特别是该药物递送系统可应用于可控药物递送的可视化。
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