Ganoderma lucidum (G. lucidum) main attractive pharmacological characteristics are antitumor and immunomodulatory activities which are chiefly associated with its two principal bioactive compounds, those are polysaccharides and triterpenoids. Ganoderic acids (GAs) are one of the most discovered triterpenoids of G. lucidum among various triterpenoids. The prominent medicinal mushroom G. lucidum possesses GAs as essential bioactive constituents that are highly oxygenated lanostane-type triterpenoids. GAs exhibit diverse potential action against numerous diseases such as anticancer, antioxidant, anti-inflammatory, anti-HIV, cardioprotective, antiallergic, antihepatotoxic, neuroprotective and antinociceptive properties. GAs act through different mechanisms that include cytotoxic, apoptosis, inducing cell cycle arrest, inhibition of topoisomerases, antiproliferation, anti-invasion, inhibition of NF-kB AP1/uPA, farnesyl protein transferase and JAK-STAT3 pathway. The miraculous effects of GAs fascinate the researchers for their production. Various environmental factors such as biochemical signals, nutritional and physical that influence the biosynthesis of GA. However, the scarcities of pure compounds or accurately characterized extracts are the main problem of clinical studies. Substantial steps are required for characterized extracts of active compounds. This review contributes a thorough insight into the mode of actions of GAs and their possible reinforcements to overcome various diseases.

灵芝（G. lucidum）的主要药理特征是抗肿瘤和免疫调节活性，这主要与其两种主要的生物活性化合物有关，即多糖和三萜类化合物。灵芝酸（气体）的大部分发现三萜类化合物的一个灵芝各种三萜类化合物之一。著名的药用蘑菇G. lucidum拥有 GAs 作为重要的生物活性成分，它们是高度氧化的羊毛甾烷型三萜类化合物。GAs 对多种疾病表现出不同的潜在作用，例如抗癌、抗氧化、抗炎、抗 HIV、心脏保护、抗过敏、抗肝毒性、神经保护和镇痛特性。GAs 通过不同的机制发挥作用，包括细胞毒性、细胞凋亡、诱导细胞周期停滞、抑制拓扑异构酶、抗增殖、抗侵袭、抑制 NF-kB AP1/uPA、法尼基蛋白转移酶和 JAK-STAT3 途径。GAs 的神奇效果让研究人员着迷于他们的生产。影响GA生物合成的各种环境因素，如生化信号、营养和物理。然而，纯化合物或准确表征的提取物的稀缺性是临床研究的主要问题。活性化合物的特征提取物需要大量步骤。这篇综述有助于深入了解 GA 的作用方式及其可能的增强作用以克服各种疾病。