Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones,Chemical Communications

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Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones
Chemical Communications ( IF 4.3 ) Pub Date : 2021-12-24 , DOI: 10.1039/d1cc06964k
Yun Dai _{1,

2} , Wei Meng _{1,

2} , Xiangqing Feng _{1,

2} , Haifeng Du _{1,

2}

Affiliation

The asymmetric hydrogenation of fluorinated olefins is an efficient pathway towards the synthesis of chiral fluorine-containing compounds. This paper described metal-free asymmetric hydrogenation of 3-fluorinated chromones with the use of readily available achiral borane and chiral oxazoline as an FLP catalyst for the first time. A variety of optically active 3-fluorochroman-4-ones were obtained in high yields with up to 88% ee.

中文翻译：

手性 FLP 催化的 3-氟化色酮的不对称氢化

氟化烯烃的不对称氢化是合成手性含氟化合物的有效途径。本文首次描述了使用容易获得的非手性硼烷和手性恶唑啉作为 FLP 催化剂的 3-氟化色酮的无金属不对称氢化。以高达 88% ee 的高产率获得了多种光学活性 3-fluorochroman-4-one。

更新日期：2022-01-11

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