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New associations of serum β-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2022-01-08 , DOI: 10.1002/fsn3.2705 Ingrida Domarkienė 1 , Asta Mažeikienė 2 , Guostė Petrauskaitė 1 , Zita Aušrelė Kučinskienė 2 , Vaidutis Kučinskas 1
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2022-01-08 , DOI: 10.1002/fsn3.2705 Ingrida Domarkienė 1 , Asta Mažeikienė 2 , Guostė Petrauskaitė 1 , Zita Aušrelė Kučinskienė 2 , Vaidutis Kučinskas 1
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Variation in carotenoid bioavailability at individual and population levels might depend on host-related factors where genetic variation has a part to play. It manifests itself through the proteins involved in carotenoid intestinal absorption and metabolism, blood lipoprotein transport, or tissue uptake. This study aims to identify novel SNPs which could be associated with carotenoid serum concentrations. A total of 265 self-reported healthy individuals of Lithuanian origin were genotyped (Illumina HumanOmniExpress-12v1.0 or v1.1 and Infinium OmniExpress-24v1.2 arrays) and fasting blood serum concentrations of β- and α-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin were measured (Shimadzu Prominence HPLC system). According to the individual carotenoid concentrations, the cohort was subdivided into quartiles. Q1 and Q4 were used for the following association analysis. The set of 2883 SNPs in 109 potential candidate genes (assumed for a direct or indirect role in carotenoid bioavailability) was analyzed. Liver X receptor alpha (NR1H3) “transport” polymorphisms rs2279238 (p = 2.129 × 10−5) and rs11039155 (p = 2.984 × 10−5), and apolipoprotein B (APOB) “transport” polymorphism rs550619 (p = 4.844 × 10−5) were associated with higher zeaxanthin concentration. Retinol dehydrogenase 12 (RDH12) “functional partner” polymorphism rs756473 (p = 7.422 × 10−5) was associated with higher lycopene concentration. Twenty-one cytochrome P450 (CYP2C9, CYP2C18, and CYP2C19) “metabolism” polymorphisms in locus 10q23.33 were significantly associated with higher β-carotene concentration. To conclude, four novel genomic loci were found to be associated with carotenoid serum levels. Zeaxanthin, lycopene, and β-carotene serum concentrations might depend on genetic variation in NR1H3, APOB, RDH12 and CYP2C9, CYP2C18, and CYP2C19 genes.
中文翻译：
血清 β-胡萝卜素、番茄红素和玉米黄质浓度与 NR1H3、APOB、RDH12 和 CYP 基因的新关联
类胡萝卜素生物利用度在个体和群体水平上的变化可能取决于宿主相关因素，其中遗传变异发挥了作用。它通过参与类胡萝卜素肠道吸收和代谢、血液脂蛋白转运或组织摄取的蛋白质表现出来。本研究旨在鉴定可能与类胡萝卜素血清浓度相关的新 SNP。对总共 265 名立陶宛裔自我报告的健康个体进行了基因分型（Illumina HumanOmniExpress-12v1.0 或 v1.1 和 Infinium OmniExpress-24v1.2 阵列）以及 β- 和 α-胡萝卜素、β-隐黄质的空腹血清浓度、番茄红素、叶黄素和玉米黄质进行测量（岛津 Prominence HPLC 系统）。根据个体类胡萝卜素浓度，队列被细分为四分位数。Q1和Q4用于以下关联分析。分析了 109 个潜在候选基因中的 2883 个 SNP（假设在类胡萝卜素生物利用度中具有直接或间接作用）。肝脏X受体α（NR1H3）“运输”多态性rs2279238（p =2.129×10−5 ）和rs11039155（p =2.984×10−5 ），以及载脂蛋白B（APOB）“运输”多态性rs550619（p =4.844×10）-5 ) 与较高的玉米黄质浓度相关。视黄醇脱氢酶 12 ( RDH12 )“功能伴侣”多态性 rs756473 ( p = 7.422 × 10 -5 ) 与较高的番茄红素浓度相关。位点 10q23.33 中的21 个细胞色素 P450（CYP2C9、CYP2C18和CYP2C19）“代谢”多态性与较高的 β-胡萝卜素浓度显着相关。总之，发现四个新的基因组位点与类胡萝卜素血清水平相关。玉米黄质、番茄红素和 β-胡萝卜素的血清浓度可能取决于NR1H3、APOB、RDH12和CYP2C9、CYP2C18和CYP2C19基因的遗传变异。
更新日期：2022-01-08
中文翻译：
血清 β-胡萝卜素、番茄红素和玉米黄质浓度与 NR1H3、APOB、RDH12 和 CYP 基因的新关联
类胡萝卜素生物利用度在个体和群体水平上的变化可能取决于宿主相关因素，其中遗传变异发挥了作用。它通过参与类胡萝卜素肠道吸收和代谢、血液脂蛋白转运或组织摄取的蛋白质表现出来。本研究旨在鉴定可能与类胡萝卜素血清浓度相关的新 SNP。对总共 265 名立陶宛裔自我报告的健康个体进行了基因分型（Illumina HumanOmniExpress-12v1.0 或 v1.1 和 Infinium OmniExpress-24v1.2 阵列）以及 β- 和 α-胡萝卜素、β-隐黄质的空腹血清浓度、番茄红素、叶黄素和玉米黄质进行测量（岛津 Prominence HPLC 系统）。根据个体类胡萝卜素浓度，队列被细分为四分位数。Q1和Q4用于以下关联分析。分析了 109 个潜在候选基因中的 2883 个 SNP（假设在类胡萝卜素生物利用度中具有直接或间接作用）。肝脏X受体α（NR1H3）“运输”多态性rs2279238（p =2.129×10−5 ）和rs11039155（p =2.984×10−5 ），以及载脂蛋白B（APOB）“运输”多态性rs550619（p =4.844×10）-5 ) 与较高的玉米黄质浓度相关。视黄醇脱氢酶 12 ( RDH12 )“功能伴侣”多态性 rs756473 ( p = 7.422 × 10 -5 ) 与较高的番茄红素浓度相关。位点 10q23.33 中的21 个细胞色素 P450（CYP2C9、CYP2C18和CYP2C19）“代谢”多态性与较高的 β-胡萝卜素浓度显着相关。总之，发现四个新的基因组位点与类胡萝卜素血清水平相关。玉米黄质、番茄红素和 β-胡萝卜素的血清浓度可能取决于NR1H3、APOB、RDH12和CYP2C9、CYP2C18和CYP2C19基因的遗传变异。
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