多功能仿生纳米酶对肿瘤微环境响应的自级联催化协同化学/化学动力学治疗,Journal of Materials Chemistry B

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多功能仿生纳米酶对肿瘤微环境响应的自级联催化协同化学/化学动力学治疗
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-01-06 , DOI: 10.1039/d1tb01891d
Nannan Zheng _{1,

2} , Yang Fu _{3,

4} , Xijian Liu ₁ , Ziwen Zhang ₁ , Jinxia Wang ₁ , Qixiang Mei _{3,

4} , Xingyan Wang ₁ , Guoying Deng ₅ , Jie Lu ₁ , Junqing Hu _{2,

6}

Affiliation

化学动力学疗法（CDT）是一种新兴的基于肿瘤微环境（TME）的癌症治疗方法，但其有限的内源性过氧化氢（H ₂ O ₂）含量削弱了抗癌作用。在此，制备了一种多功能仿生纳米酶（Se@SiO ₂ -Mn@Au/DOX，命名为 SSMA/DOX），它经过 TME 响应的自级联催化，以促进 MRI 引导的增强化学/化学动力学治疗。SSMA/DOX 纳米复合材料 (NCs) 在肿瘤的酸性条件下响应降解以释放 Se、DOX、Au 和 Mn ²⁺。Mn ²⁺不仅使MRI能够指导治疗，而且催化内源性H ₂ O ₂转化为 CDT 的羟基自由基 (˙OH)。此外，Au NPs持续催化葡萄糖生成H ₂ O ₂，通过补充足够的反应性材料来增强CDT，并通过消耗葡萄糖来切断肿瘤的能量供应。同时，硒通过上调肿瘤细胞内的活性氧，增强了盐酸阿霉素（DOX）和CDT的化疗作用，对肿瘤具有显着的抑制作用。此外，SSMA/DOX NCs 具有良好的生物相容性和可降解性，避免了长期毒性和副作用。总体而言，可降解的 SSMA/DOX NCs 为肿瘤微环境响应性自级联催化提供了一种创新策略，以增强肿瘤治疗。

"点击查看英文标题和摘要"

Tumor microenvironment responsive self-cascade catalysis for synergistic chemo/chemodynamic therapy by multifunctional biomimetic nanozymes

Chemodynamic therapy (CDT) is an emerging approach to treat cancer based on the tumor microenvironment (TME), but its limited content of endogenous hydrogen peroxide (H₂O₂) weakens the anticancer effects. Herein, a multifunctional biomimetic nanozyme (Se@SiO₂–Mn@Au/DOX, named as SSMA/DOX) is fabricated, which undergoes TME responsive self-cascade catalysis to facilitate MRI guided enhanced chemo/chemodynamic therapy. The SSMA/DOX nanocomposites (NCs) responsively degrade in acidic conditions of tumor to release Se, DOX, Au and Mn²⁺. Mn²⁺ not only enables MRI to guided therapy, but also catalyzes the endogenous H₂O₂ into hydroxyl radical (˙OH) for CDT. In addition, the Au NPs continuously catalyze glucose to generate H₂O₂, enhancing CDT by supplementing a sufficiently reactive material and cutting off the energy supply of the tumor by consuming glucose. Simultaneously, Se enhances the chemotherapy of doxorubicin hydrochloride (DOX) and CDT by upregulating ROS in the tumor cells, achieving remarkable inhibition effect towards tumor. Moreover, SSMA/DOX NCs have good biocompatibility and degradability, which avoid long-term toxicity and side effects. Overall, the degradable SSMA/DOX NCs provide an innovative strategy for tumor microenvironment responsive self-cascade catalysis to enhance tumor therapy.

更新日期：2022-01-06

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