In recent years, cyclobutyl has become more influential in the field of drug design. Its unique four-membered ring structure is not only a useful intermediate for the synthesis of biomedical candidate materials but also an indispensable framework for drug design and application. According to the therapeutic field, cyclobutyl drugs are roughly divided into tumor and cancer drugs, nervous system drugs, analgesics, antiviral drugs, and gastrointestinal drugs. Among them, platinum-based anticancer drugs containing cyclobutyl fragments have achieved remarkable success in the treatment of cancer, bringing new hope for the development of more cyclobutyl drugs. This article provides details of the research progress of the structure types, structure-activity relationships, targets, and mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.

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含有环丁基片段的分子作为治疗工具：环丁基药物综述。

近年来，环丁基在药物设计领域的影响力越来越大。其独特的四元环结构不仅是合成生物医学候选材料的有用中间体，也是药物设计和应用不可或缺的框架。根据治疗领域，环丁基类药物大致分为肿瘤和癌症药物、神经系统药物、镇痛药、抗病毒药物和胃肠道药物。其中，含环丁基片段的铂类抗癌药物在治疗癌症方面取得了显着的成功，为开发更多的环丁基药物带来了新的希望。本文详细介绍了结构类型、构效关系、靶点、