Rare Metals ( IF 9.6 ) Pub Date : 2021-08-19 , DOI: 10.1007/s12598-021-01808-y Mian Chen 1 , Xiao-Qiao Wang 1 , Yi-Zao Wan 1 , Jian Hu 1 , Er-Lin Zhang 2
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Biomaterial surfaces with satisfied antibacterial activity and appropriate cytocompatibility are a pressing clinical need for orthopedic and dental implants. Fluorine-containing biomaterials have been demonstrated to obtain antibacterial activity and osteogenic property, while the effect of fluorine chemical compositions on antibacterial property and cytocompatibility is rarely studied. To this end, the coatings with different fluorine chemical compositions on titanium surface were prepared by plasma treatment to verify the antibacterial ability and cytocompatibility of fluorinated surfaces. Their antibacterial ability was evaluated by using Staphylococcus aureus, and the cell compatibility was investigated with MC3T3-E1 cells in vitro. The results show that both fluorocarbon coating and metal fluorides coating exhibited a hydrophilic and nano-scaled roughness. Rather than the fluorocarbon coating, the coating composed of metal fluorides presented satisfied bactericide effect and excellent cytocompatibility. The antibacterial mechanism is associated with the metal fluorides and released fluoride ion. This work would provide novel sight in optimizing the surface modification method of fluorinated biomaterials for biomedical applications.
Graphical abstract
中文翻译：
等离子表面改性氟化钛的抗菌能力和生物相容性
具有令人满意的抗菌活性和适当的细胞相容性的生物材料表面是骨科和牙科植入物的迫切临床需求。含氟生物材料已被证明具有抗菌活性和成骨性能，而氟化学成分对抗菌性能和细胞相容性的影响却鲜有研究。为此，通过等离子体处理在钛表面制备了具有不同氟化学成分的涂层，以验证氟化表面的抗菌能力和细胞相容性。用金黄色葡萄球菌评价它们的抗菌能力，并在体外研究了与 MC3T3-E1 细胞的细胞相容性。结果表明，氟碳涂层和金属氟化物涂层均表现出亲水性和纳米级粗糙度。与氟碳涂层相比，由金属氟化物组成的涂层表现出令人满意的杀菌效果和优异的细胞相容性。抗菌机制与金属氟化物和释放的氟离子有关。这项工作将为优化用于生物医学应用的氟化生物材料的表面改性方法提供新的视角。
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