An efficient synthesis of indolizines with a thioether group is developed through employing [4+2]-annulation of N-substituted pyrrole-2-carboxaldehydes and prop-2-ynylsulfonium salts, forming a wide variety of target compounds with various substituents and functionalities in moderate to good yields. The success of this transformation makes it an alternative approach to previous protocols, and pharmaceutical and biomedical applications of the investigated compounds are expected with further development.

中文翻译：

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[4+2]-prop-2-ynylsulfonium 盐和 N-取代的 pyrrole-2-carboxaldehydes 的环化：获得含有硫醚基团的 indolizines

通过使用 N-取代的吡咯-2-甲醛和丙-2-炔锍盐的[4+2]-环化，开发了一种具有硫醚基团的吲哚茚的有效合成，形成具有各种取代基和官能团的多种目标化合物。中等至良好的产量。这种转变的成功使其成为以前协议的替代方法，预计所研究化合物的药物和生物医学应用将得到进一步发展。