Quinoxalinones are a class of heterocyclic compounds which attract extensive attention owing to their potential in the field of organic synthesis and medicinal chemistry. During the past few decades, many new synthetic strategies toward the functionalization of quinoxalinone based scaffolds have been witnessed. Regrettably, there are only a few reports on the pharmacological activities of quinoxalinone scaffolds from a medicinal chemistry perspective. Therefore, herein we intend to outline the applications of multifunctional quinoxalinones as privileged structures possessing various biological activities, including anticancer, neuroprotective, antibacterial, antiviral, antiparasitic, anti-inflammatory, antiallergic, anti-cardiovascular, anti-diabetes, antioxidation, etc. We hope that this review will facilitate the development of quinoxalinone derivatives in medicinal chemistry.

喹喔啉酮类化合物是一类杂环化合物，因其在有机合成和药物化学领域的潜力而受到广泛关注。在过去的几十年中，人们见证了许多基于喹喔啉酮的支架功能化的新合成策略。遗憾的是，从药物化学角度研究喹喔啉酮支架的药理活性的报道很少。因此，本文中我们打算概述多功能喹喔啉酮作为具有多种生物活性的特殊结构的应用，包括抗癌、神经保护、抗菌、抗病毒、抗寄生虫、抗炎、抗过敏、抗心血管、抗糖尿病、抗氧化等。希望本次综述能够促进喹喔啉酮衍生物在药物化学领域的发展。