Eight new monoterpenoid indole alkaloids, alstoyunines A−H (1−8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC₅₀ = 3.89 μM) and hepatocellular carcinoma SMMC-7721 (IC₅₀ = 21.73 μM) cell lines.

中文翻译：

---

云南阿尔斯通单萜类吲哚生物碱

八个新单萜吲哚生物碱，alstoyunines A-H（1 - 8）中，用17个已知类似物一起，被从分离鸡骨常山南松。新生物碱的结构是通过广泛的光谱方法建立的。Alstoyunines C（3），E（5）和F（6）显示出对Cox-2（> 75％）的选择性抑制。Alstoyunine F（6）对人骨髓白血病HL-60（IC ₅₀ = 3.89μM）和肝细胞癌SMMC-7721（IC ₅₀ = 21.73μM ）细胞毒性较弱。