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Toxicological Effect and Molecular Mechanism of the Chiral Neonicotinoid Dinotefuran in Honeybees
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-12-30 , DOI: 10.1021/acs.est.1c05692 Quan Zhang 1 , Lili Fu 1 , Tao Cang 2 , Tao Tang 2 , Mingcheng Guo 3 , Bingbing Zhou 4 , Guohua Zhu 4 , Meirong Zhao 1
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-12-30 , DOI: 10.1021/acs.est.1c05692 Quan Zhang 1 , Lili Fu 1 , Tao Cang 2 , Tao Tang 2 , Mingcheng Guo 3 , Bingbing Zhou 4 , Guohua Zhu 4 , Meirong Zhao 1
Affiliation
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With the increasing demand for pollinating services, the wellness of honeybees has received widespread attention. Recent evidence indicated honeybee health might be posed a potential threat by widely used neonicotinoids worldwide. However, little is known about the molecular mechanism of these insecticides in honeybees especially at an enantiomeric level. In this study, we selected two species of bees, Apis mellifera (A. mellifera) and Apis cerana (A. cerana), to assess the toxicity and molecular mechanism of neonicotinoid dinotefuran and its enantiomers. The results showed that S-dinotefuran was more toxic than rac-dinotefuran and R-dinotefuran to honeybees by oral and contact exposures as much as 114 times. A. cerana was more susceptible to highly toxic enantiomer S-dinotefuran. S-dinotefuran induced the immune system response in A. cerana after 48 h exposure and significant changes were observed in the neuronal signaling of A. mellifera under three forms of dinotefuran exposure. Moreover, molecular docking also revealed that S-dinotefuran formed more hydrogen bonds than R-dinotefuran with nicotinic acetylcholine receptor, indicating the higher toxicity of S-dinotefuran. Data provided here show that R-dinotefuran may be a safer alternative to control pests and protect pollinators than rac-dinotefuran.
中文翻译：
手性新烟碱呋虫胺对蜜蜂的毒理学作用及分子机制
随着授粉服务需求的不断增加，蜜蜂的健康受到了广泛关注。最近的证据表明，全球广泛使用的新烟碱类物质可能对蜜蜂的健康构成潜在威胁。然而，人们对这些杀虫剂在蜜蜂中的分子机制知之甚少，尤其是在对映体水平上。在这项研究中，我们选择了两种蜜蜂，蜜蜂（A. mellifera）和蜜蜂（A. cerana）来评估新烟碱类呋虫胺及其对映体的毒性和分子机制。结果表明，S-呋虫胺的毒性比rac-呋虫胺和R-呋虫胺对蜜蜂的口服和接触暴露多达 114 次。A. cerana对剧毒对映体S-呋虫胺更敏感。S-呋虫胺在暴露48小时后诱导了中华蜜蜂的免疫系统反应，并且在三种形式的呋虫胺暴露下观察到蜜蜂花的神经元信号发生了显着变化。此外，分子对接还显示S-呋虫胺与烟碱型乙酰胆碱受体形成的氢键多于R-呋虫胺，表明S-呋虫胺具有更高的毒性。此处提供的数据表明，R-dinotefuran 可能是比rac -dinotefuran 更安全的替代品来控制害虫和保护传粉媒介。
更新日期：2022-01-18
中文翻译：
手性新烟碱呋虫胺对蜜蜂的毒理学作用及分子机制
随着授粉服务需求的不断增加，蜜蜂的健康受到了广泛关注。最近的证据表明，全球广泛使用的新烟碱类物质可能对蜜蜂的健康构成潜在威胁。然而，人们对这些杀虫剂在蜜蜂中的分子机制知之甚少，尤其是在对映体水平上。在这项研究中，我们选择了两种蜜蜂，蜜蜂（A. mellifera）和蜜蜂（A. cerana）来评估新烟碱类呋虫胺及其对映体的毒性和分子机制。结果表明，S-呋虫胺的毒性比rac-呋虫胺和R-呋虫胺对蜜蜂的口服和接触暴露多达 114 次。A. cerana对剧毒对映体S-呋虫胺更敏感。S-呋虫胺在暴露48小时后诱导了中华蜜蜂的免疫系统反应，并且在三种形式的呋虫胺暴露下观察到蜜蜂花的神经元信号发生了显着变化。此外，分子对接还显示S-呋虫胺与烟碱型乙酰胆碱受体形成的氢键多于R-呋虫胺，表明S-呋虫胺具有更高的毒性。此处提供的数据表明，R-dinotefuran 可能是比rac -dinotefuran 更安全的替代品来控制害虫和保护传粉媒介。
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