自闭症谱系与睡眠-觉醒特征之间的关系,Autism Research

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自闭症谱系与睡眠-觉醒特征之间的关系
Autism Research ( IF 5.3 ) Pub Date : 2021-12-29 , DOI: 10.1002/aur.2660
Stacey D Elkhatib Smidt _{1,

2,

3} , Arpita Ghorai ₄ , Sara C Taylor _{4,

5} , Brielle N Gehringer _{4,

5} , Holly C Dow _{4,

5} , Allison Langer _{4,

5} , Eric Rawot _{4,

5} , Jing Zhang ₆ , Jonathan A Mitchell _{7,

8} , Daniel J Rader ₄ , Laura Almasy _{4,

9,

10} , Edward S Brodkin ₅ , Maja Bućan ₄

Affiliation

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sleep Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Graduate Group in Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Lifespan Brain Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

自闭症儿童和成人经常出现睡眠障碍，这可能会影响他们和家人的生活质量。然而，睡眠-觉醒模式与自闭症谱系特征之间的关系尚未得到充分研究。识别这种关系可能会导致未来的研究阐明共同的机械基础。因此，我们旨在确定睡眠-觉醒模式，特别是与睡眠、身体活动和每日睡眠-觉醒节律（即昼夜节律）相关的睡眠-觉醒模式是否与自闭症谱系相关特征相关。在具有自闭症谱系特征的个体及其家庭成员中估计加速度计衍生的睡眠-觉醒参数（N = 267)。我们使用社会反应量表 (SRS) 评估自闭症谱系特征来评估社会障碍的存在和严重程度，并使用执行功能行为评定量表 (BRIEF) 来评估执行功能。线性多元回归分析（使用 SOLAR-Eclipse）表明，在成年人中，核心自闭症谱系特征和执行功能障碍的增加与几个睡眠-觉醒参数的中断有关，特别是与日常睡眠-觉醒节律有关，而执行功能障碍是与睡眠质量和身体活动水平的紊乱有关。我们强调了白天功能和睡眠-觉醒模式中断之间的相互作用，特别是与日常睡眠-觉醒节律有关，这可以指导未来对常见机制的研究。

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The relationship between autism spectrum and sleep–wake traits

Autistic children and adults often have sleep disturbances, which may affect their and their family's quality of life. Yet, the relationship between sleep–wake patterns and autism spectrum traits is understudied. Identifying such relationships could lead to future research elucidating common mechanistic underpinnings. Thus, we aimed to determine whether sleep–wake patterns, specifically related to sleep, physical activity, and the daily sleep–wake rhythm (i.e., circadian rhythm), are associated with autism spectrum-related traits. Accelerometer-derived sleep–wake parameters were estimated in individuals with autistic spectrum traits and their family members (N = 267). We evaluated autism spectrum traits using the Social Responsiveness Scale (SRS) to assess the presence and severity of social impairment and the Behavior Rating Inventory of Executive Function (BRIEF) to assess executive function. The linear multivariate regression analysis (using SOLAR-Eclipse) showed that in adults, increased core autism spectrum traits and executive dysfunction were associated with disruption of several sleep–wake parameters, particularly related to the daily sleep–wake rhythm, and that executive dysfunction was associated with disrupted sleep quality and level of physical activity. We highlight the interplay between daytime function and disrupted sleep–wake patterns, specifically related to the daily sleep–wake rhythm, that could guide future research into common mechanisms.

更新日期：2021-12-29

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