A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligand and diverse transformations.

中文翻译：

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Pd催化的对映选择性分子内Heck反应获得具有末端烯烃的二取代二氢异喹啉酮

开发了第一个钯催化的不对称分子内 Heck 反应，用于构建含有季碳手性中心的 3,4-二氢-1-(2H)-异喹啉酮。该反应的显着特点包括高效、高对映选择性、新型手性配体和多种转化。